LIPOPROTEINS, PRIONS, AND MOLECULAR CLOCKS

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LIPOPROTEINS, PRIONS, AND MOLECULAR CLOCKS
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Lipoproteins

• HDL/ LDL/ VLDL

• LDL Low Density Lipoprotein

• VLDL Very Low Density Lipoprotein

• HDL High Density Lipoprotein

• LDL and VLDL are delivery trucks

• from the liver to the cells

• HDL are garbage trucks

• from cells and tissues to the liver

• Butter, margarine, olive oil

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Prions and spongiform encephalopathies
Alpha helix to Pleated sheet
Chain reaction
Bovine spongiform encephalopathy
Human Spongiform Encephalopathy

• Creutzfeldt-Jakob Disease (CJD)

• Kuru

• Transmitted and Spontaneous forms

PRP protease resistant protein
Genetic resistance in humans
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Molecular clocks
Linus Pauling
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Questions

• Which of the following is NOT true about HDL?
• It carries fat and cholesterol from cells to the
  liver
• The more the better
• It is the good cholesterol
• All of the above are true

• Why is HSE not more common?
• Most cases have not yet been diagnosed
• Most people seem to have resistance to it
• The USDA has a foolproof method of detecting
• contaminated meat
• d. Not many people eat hamburgers or hot dogs

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The end