Counterterrorism: A Cure for Anthrax

1
Counterterrorism A Cure for Anthrax

• A Proposed Method for Combating Anthrax Infection
  in Humans

2
Anthrax An Introduction

• Caused by Bacillus anthracis
• Three forms
• Cutaneous
• Not usually fatal
• Enteric
• 25-60 mortality rate
• Inhalational
• 100 mortality rate if left untreated
• Signs and Symptoms
• URI
• Dyspnea, diaphoresis, myalgia
• Septic shock

3
Anthrax The Assassins Choice

• High mortality
• Non-transmissable
• Stores for years
• Dispersion

4
Pathogenesis of Anthrax
5
The Key

• Anthrax relies on Protective Antigen (PA) to
  function (allows endocytosis of LF and EF)

6
Proposed BioBrick

• UPI0000027636
• Mus musculus version of Anthrax Toxin Receptor
• Remodel MIDAS region