Cl channel and Cl CHANNELOPATHIES

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Cl- channel and Cl- CHANNELOPATHIES

• Properties of Cl- channels
• Cl- dependent myotonia

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Skeletal muscle Cl- channel
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Skeletal muscle Cl- channel
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Skeletal muscle Cl- channel
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Cl- channel blocker,9-anthracene carboxylic acid
(9-AC)
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Cl- channel selectivity
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Cl- channel activation
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Cl- channel deactivation
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Single Cl- channel conductance
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Cl- channel is a dimer with two pores
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Nucleotide dependency of Cl- channel
CON GTP IMP cAMP
ATP
AMP
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Voltage-sensitive Cl- channel family
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Molecular structure of Voltage-sensitive Cl-
channel
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Molecular structure of Voltage-sensitive Cl-
channel
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Cl- channel Family
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Physiological role of the CFTR channel - Pancreas
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Physiological role of the CFTR channel Sweat
duct
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The CFTR channel
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The CFTR channel
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The CFTR channel
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Myotonia from Cl- channel
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Myotonia from Cl- channel
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Myotonia from Cl- channel
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Myotonia from Cl- channel
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Myotonia from Cl- channel
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Myotonia from Cl- channel
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Myotonia from Cl- channel
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Myotonic run