Promising Linkage Regions and Candidate Genes Associated With Bipolar Disorder

1
Promising Linkage Regions and Candidate Genes
Associated With Bipolar Disorder

• Linkage Regions
• 4p16, 4q35
• 6q22
• 8q24
• 12q24
• 13q31-33
• 16p12
• 18p11-q12, 18q22-23
• 21q22
• 22q11-13

• Candidate Genes
• 5-HTT Serotonin transporter
• MAOA Monoamine oxidase A
• TH Tyrosine hydroxylase
• COMT Catechol-O-methyl transferase
• DRD2 Dopamine D2 receptor
• DRD4 Dopamine D4 receptor
• BDNF Brain-derived neurotrophic factor
• G72/G30 D-amino acid oxidase activator

Large sample sizes needed for these
investigations
Goodwin F, Jamison K. Manic Depressive Illness.
Oxford University Press New York, NY 2007.