Three phases of normal wound healing:

1
Three phases of normal wound healing

• 1.
• 2.
• 3.

2
Thrombosis/ Blood Clotting

• General sequence of blood clotting
• 1.
• 2.
• 3.
• 4.
• Blood clotting/coagulation consists of two
  specific pathways
• 1. ____________ requires _____ to form a clot
• Example _________
• ____________ requires ______ to form clot
• Example __________

3
Host Defense

• Innate immune defense
• Innate immune defense involves the events of
• 1.
• 2.

4

• Inflammation events consist of
• 1.
• 2.
• 3.
• 4.
• 5.
• Inflammatory responses due to tissue injury are
• 1.
• 2.
• 3.
• 4.

5
Cells mediating normal wound healing

• 1.
• 2.
• 3.
• 4.

6
Phagocytosis

• Phagocytosis
• Phagocytes
• The most important phagocytes are ________,
  _________, __________ and __________________.

7
Phagocytosis Mechanism
8
The phase of inflammatory response
Acute Chronic Granulation
9
Body response to implant

• Healing response in the presence of implant
  involves ______________, which involves
  _____________, ______________, ____________,
  ____________ and _____________.
• Foreign body reaction depends on the geometry and
  form of implant, such as
• ____________________ layer of __________with one
  to two cells in thickness
• ____________________ multiple layers of
  ______________ and _____________
• ____________________ presence of ______________
  and ___________ with varying degree of
  granulation tissues

10

• Implant material is in contact with blood and
  lymph (interstitial fluid), which the fluid
  portion is called ___________.
• Plasma consists of 92 water and other
  components, which are highest in ___________.
  Therefore, protein ___________ on the surface of
  implant.
• Protein adsorption is influenced by ___________
  and ______________.
• After protein adsorption, proteins still undergo
  __________________, as a result of
  _________________ and ________________.
• Vroman effect

11

• Three possible outcome of implant
• 1.
• 2.
• 3.
• Thickness of fibrous encapsulation depends on
  _____________ and _____________.