Atypical Antipsychotics

1
Atypical Antipsychotics

• Advantages
• Low EPS and TD liability
• Prolactin sparing with most
  drugs
• Improvement in cognitive deficits
• Advantages in some refractory patients

• Limitations
• Metabolic side effects with some (eg, weight
  gain)
• EPS liability with some drugs at high doses
• Somnolence
• Inadequate response in many
  patients

EPS extrapyramidal symptoms TD tardive
dyskinesia
Meltzer HY. Neuropsychopharm. 199921(suppl)106S-
115S.