Volumetric Visualization and Analysis: Introduction and Clinical Benefits

1
Vascular Centerline Determination for CPR and
Quantitative Applications
2
Vascular Centerline Fitting in the Presence of
Occlusion

• Adequate techniques for patent vessels
• Occluded segments are not opacified by contrast
  agent and, therefore, are isodense with tissue.
• Difficult to visualize and extract manually or
  automatically.

3
Knowledge-based Interpolation of Curves

• Use database of extracted centerlines
• Fit patent portions of occluded vessel to
  principal components of database
• Use fitted centerline to interpolate occluded
  segment

T. Rakshe, D. Fleischmann , J. Rosenberg, J.
Roos, S. Napel, Knowledge-Based Interpolation of
Curves Application to Femoropopliteal Arterial
Centerline, Medical Image Analysis 11(2)157-68,
April 2007.
4
Knowledge-based Interpolation of Curves
Experiments in Simulated Occlusions

• 30 patients w/o peripheral vascular disease in
  fem-pop artery
• Simulated occlusions of various lengths in each
• Fit patent portion to PCA of database formed from
  other 29

T. Rakshe, D. Fleischmann , J. Rosenberg, J.
Roos, S. Napel, Knowledge-Based Interpolation of
Curves Application to Femoropopliteal Arterial
Centerline, Medical Image Analysis 11(2)157-68,
April 2007.
5
Knowledge-based Interpolation of Curves
Experiments in Simulated Occlusions

• 30 patients w/o peripheral vascular disease in
  fem-pop artery
• Simulated occlusions of various lengths in each
• Fit patent portion to PCA of database formed from
  other 29

Interpolated centerline will stay within radius
of fem-pop artery for occlusions up to between 75
and 100 mm
T. Rakshe, D. Fleischmann , J. Rosenberg, J.
Roos, S. Napel, Knowledge-Based Interpolation of
Curves Application to Femoropopliteal Arterial
Centerline, Medical Image Analysis 11(2)157-68,
April 2007.
6
Contralateral-based Interpolation of Occluded
Segments
Experiments in Simulated Occlusions and Patient
Data
Methods

• 29 patients w/o peripheral vascular disease in
  fem-pop artery
• Simulated occlusions of various lengths in each
• Fit patent contralateral artery to interpolate
  occluded segment compared to PCA method
• Similar experiment in 5 patients with occlusions
• reference standard hand-traced
• compared to PCA

D. N. Tran, D. Fleischmann, T. Rakshe, J. E.
Roos, J. Rosenberg, M. Straka, S. Napel,
Femoropopliteal artery centerline interpolation
using contralateral shape, accepted pending
revision, Medical Image Analysis, May 2007.
7
Contralateral-based Interpolation of Occluded
Segments
Example in a 145 mm Occlusion
Centerline
Patent
Interpolated
8 Expert Tracings
Expert
Algorithm
CPR
lat-long
lat-long
AP-long
AP-long
8
Contralateral-based Interpolation of Occluded
Segments
Experiments in Simulated Occlusions and Patient
Data
Results

• Contralateral similar to PCA
• PCA slightly better in simulations (normal
  subjects)
• Better than PCA in 5 patients

D. N. Tran, D. Fleischmann, T. Rakshe, J. E.
Roos, J. Rosenberg, M. Straka, S. Napel,
Femoropopliteal artery centerline interpolation
using contralateral shape, accepted pending
revision, Medical Image Analysis, May 2007.
9
Improved Interpolation using Intermediate Points
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