Small Animal Radiation Therapy MicroRT

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Small Animal Radiation Therapy (MicroRT)

• Team Paragative
• Neil Mehta
• Sumona Nag
• Claudiu Diaconu

Mentors Parag Parikh, M.D. Strahinja
Stojadinovic, PhD
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Need

• Mice are good models for treatment of tumors with
  irradiation
• No device available to allow conformal therapy

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Gamma Knife System

• Collimator

• Components
• 1o collimator
• 2o collimator
• Inserts
• Stage
• Mouse Holder

http//www.answers.com/gamma20knife
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Design Specifications
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Inserts

• 3 Models

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Shaping the Beam

• Many inserts with different inner radii
• Blocks

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Shape of 1o collimator

• 3 options
• Shell
• Square prism
• Cylinder

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Shape of 1o collimator

• Shell
• Resembles Gamma knife

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Shape of 1o collimator

• Square Prism

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Shape of 1o collimator

• Cylindrical

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Pugh Charts
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Stage

• 3 options
• All capable of rotating

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Stage
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Stage Pugh Chart
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Mouse Holder

• Existing Design

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Mouse Holder

• Problem Mouse is too far from source

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Mouse Holder

• Proposed Design

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Mouse Holder

• Problem Solved

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1o Collimator Material

• Materials usually used
• Titanium, Stainless Steel
• Too heavy
• Proposed material
• Aluminum
• Lightweight, cheap

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2o Collimator Material

• Materials usually used
• Tungsten, Lead
• Proposed material
• Tungsten
• More dense blocks stray radiation best

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Example

• Irradiate mouse at angle shown

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Example
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Updated Design Schedule
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Team Organization

• Claudiu- Labview, DesignSafe, Progress Report
  Presentation
• Sumona Mechanical Drawings, Webpage, Final
  Report Presentation
• Neil Weekly Reports, Drafting Papers, Team
  Leader, Preliminary Report Presentation

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Questions?