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ENTREZ PubMed

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From: Computational Proteomics, Mark B Gerstein, Yale U. The Globin Story. Bio-informatics ... (after nearly 20 years of work) the structure of two related proteins: ... – PowerPoint PPT presentation

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Title: ENTREZ PubMed


1
NCBI
ENTREZ - PubMed
2
Post-genomic terms (Oct. 2002)
Google search
PubMed
2.1x106 76,566
Genome Proteome Transcriptome Gene
function Metabolome Glycome
89,300 1,701
9,960 229
1.2x106 6.5x105
1,170 29
138 6
From Computational Proteomics, Mark B Gerstein,
Yale U.
3
The Globin Story
Bio-informatics Tour Highlights
3
4
Red Blood Cells
  • Carry oxygen from the lungs.
  • Carry carbon dioxide back to the lungs.
  • Live 120 days.
  • Contain hemoglobin.
  • Made from iron, Folic acid and
  • vitamin B12, in the bone marrow.

5
1962 Nobel Prize (Chemistry)
In 1953, Max Perutz and John Kendrew of
Cambridge University found (after nearly 20
years of work) the structure of two related
proteins hemoglobin, which carries oxygen in
the blood, and myoglobin, which stores oxygen in
the muscles.
The opening of the door" to a new world of
understanding living organisms.
6
Similarity / Analogy
Examples If looks like an elephant, and smells
like an elephant its an elephant. If walks
like a duck, and quacks like a duck its a
duck.
http//cbms.st-and.ac.uk/academics/ryan/Teaching/m
olbiol/Bioinf_files/v3_document.htm
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