Protein 3D structures

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Bioinformatics Biomolecule Modeling

• Protein 3D structures
• Genome sequences
• Bix application tools and databases

Ming-Jing Hwang IBMS, Academia Sinica
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Bioinformatics, 1998
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• Unique Capabilities
• alternative alignments allowing sub-domain motif
  (structural building block) discovery
• permutation detection at all levels of
  complexity

Bioinformatics, 2003 Proteins, 2004
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Scrambled Protein Pair
few, if any, are able to detect permutations
directly. - Robert B. Russell (2002)
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Str. Bioinformatics databases
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• We are holding so many
• genomes,
• we need a genome positioning system (GPS)
• -- the UniMarker (UM) method

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marker-based Genome Positioning System (mGPS)
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Genomics Bix tools/databases
(for SNP mapping Genome Res. 2002)
(Bioinformatics, 2004)
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The Team