CENTRAL DOGMA OF BIOLOGY

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CENTRAL DOGMA OF BIOLOGY
DNA
RNA
PROTEIN
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Splicing Signals
Major introns
3' Splice Site
Branch Site
5' Splice Site
18-40 nts
Py-tract
Minor introns
AC
AT
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Yeast
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Base-pairing
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Similarities
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Group I
Ist
Reverse of Ist
Rp
Sp
Rp
2nd
2nd
Sp
Rp
Rp
Reverse of IInd
Rp
Intron insertion
Group II Pre-mRNA
Ist
Ist
Rp
Sp
Rp
2nd
2nd
Rp
Sp
Rp
NP1(Sp)
RNase T1, SVPD (Rp)
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ATP and DEAD-box proteins Participate in RNA-RNA
rearrangements
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Examples of RNA-RNA rearrangements
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Examples of DEAD-box proteins
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RS domain can promote RNA-RNA annealing,protein-p
rotein interactions, or both
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The End
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Two Transesterifications