Center for Infectious Disease Research and Vaccinology

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Center for Infectious Disease Research and
Vaccinology
David H. Francis, Director
Germ-free pig room Animal Resource Wing, SDSU
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Center Investigators
Collaborators William Cafruny-USD Christopher
Chase-SDSU Michael Chaussee-USD Tom
Cheesborough-SDSU Jane Christopher-Hennings-SDSU
Alan Erickson-SDSU Ying Fang-SDSU Michael
Hildreth-SDSU Radhey Kaushik-SDSU Eric
Nelson-SDSU Artur Rosa-SDSU Weiping Zhang-SDSU
Project Directors Indranil Biswas- USD Volker
Brozel-SDSU Philip Hardwidge-SDSU Feng
Li-SDSU Adhar Manna-USD Fedora
Sutton-SDSU Xiuqing Wang-SDSU Alan Young-SDSU
Microvilli of Intestinal Epithelial Cells
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Industrial Collaborators
Rural Technologies, Inc, Brookings, -STTR
Phase I (100K) and Phase II (750K
-National Pork Board Grant Hematech, LLC. Sioux
Falls, SD Tetracore, Gaithersburg, MD -Two
Diagnostic Kits developed Approx 2M in
sales in the past year
Electron micrograph of E. coli infected piglet
intestine
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Center Mission
To foster research activities that will lead to
the development of novel therapeutic and
diagnostic technologies and products for
infectious disease in humans and domestic
animals---
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What we are trying to accomplish with our 2010
grant ?
Large Animal Surgery, Animal Resource Wing, SDSU
To provide intellectual and financial resources
to investigators interested in developing
a) diagnostic tests b) vaccines and c) compounds
or procedures for prevention and treatment of
disease.
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Center Objectives
Establishing a critical research mass Becoming
internationally prominent Attracting world class
investigators Substantially increasing federal
grants Developing marketable products Stimulating
economic development in South Dakota
Researcher working in clean culture room
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How are we using the 2010 resources?
-Providing partial salary support for new faculty
-Buy-out of teaching contracts of
research-oriented existing faculty -Hiring
technical experts and purchasing new
equipment -Providing mentorship and training
opportunities for research faculty and
staff -Providing pilot funding to bring promising
ideas to readiness for competing for federal
grants or to attract corporate collaborators
Hall, Animal Resource Wing, SDSU
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National/International Need Vaccines for
diseases that attack organs through mucus
membranes
PRRS Virus
Vaccines against most serious blood-borne
(systemic) diseases of man and domestic animals
are available. However, very few vaccines
against diseases of the mucosal membranes have
been developed.
Bladder infections Bacterial and viral
diarrheas Colds and pheumonia
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Why We Can be Successful
Basic understanding of the mucus membrane
(mucosal) immunity is becoming mature and vaccine
technology is emerging We have developed the
best or only animal models for several important
diseases We possess the technical tools to
design effective vaccines
Animal Resource Wing, SDSU
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Research Targets
Mucosal Vaccine Delivery Technology Topical
Vector Transgenic plants Vaccines PRRS E. coli
O157H7 Enterotoxigenic E. coli Diagnostic
Technology Basic Science of Infection and Disease
C-Section bubble for delivery of germ-free pigs
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Discovery and Development Process

• Detection of a New Syndrome
• Identification of the Causative Agent
• Characterization of the Disease and
  Disease-Causing Agent
• Development of Diagnostic Tests
• Development of Treatment and/or Prevention
  Strategies
• Development and Marketing of Diagnostic,
  Treatment and/or Prevention Materials

Francis Back Yard, Brookings, SD
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PRRS Virus
Veterinary Clinicians detected new
syndrome Minnesota Diagnostic Lab sent specimen
to SDSU Veterinary researchers who
reproduced disease in experimental animals and
determined that the agent was a
virus Collaboration (UM, SDSU and
Boehringer- Ingelheim Vetmedica) isolated and
characterized virus Boehringer-Ingelheim
Vetmedica attenuated the virus to produce a
vaccine Virus and derived vaccine jointly
patented by UM, SDSU and BI. Vaccine widely
marketed, yielding up to 160M/ year in sales,
with about one M/year in royalties split between
UM and SDSU
Francis Back Yard, Brookings, SD
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Center SupportAwards Since Inception

• Awards
• 1,560,000 (2010 grant)
• 2,540,000 (Other Grants and Contracts)
• 4,100,000 Total
• Average per investigator 195,000

Munjac Deer model for Chronic Wasting Disease
being developed at SDSU
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Leverage of 2010 grant
Percentage of funding provided by 2010
grant 38 New dollars for every dollar
provided by 2010 grant 1.62
Research Laboratory
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Short-term Economic Impact of Center
Total Dollars from Grants about
4.1M Estimated amount entering SD economy About
3.3 M New and projected hires Five new
faculty Five new staff Fourteen new
graduate students and postdocs
Technician at DNA sequencer
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Long-Term Economic Impact of Center
Substantially increased number of federal
grants and industrial contracts Faculty/staff
expansion Major supporter of graduate
program SBIR/STTR collaborations with several
SD corporations Biotechnology support for SDSU
Research Park in Brookings, and other SD
Businesses
Graduate Student conducting PCR Test
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Plans for Center Sustainability
Enhanced application for and award of grants
and contracts, including collaborations with
other consortia. Federal Centers Grants
NIH COBRE is current target-up to 12M over
a 5 year period Shared FA resources
Endowments and other gifts Enhanced
professorships.
Francis back yard
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What Do These Places Have in Common?
Ames, IA Bozeman, MT
Columbia, MO Ft Collins, CO
Logan, UT Provo, UT
Research laboratory
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What Do These Places Have in Common?
Ames, IA Bozeman, MT Columbia,
MO Ft Collins, CO Logan, UT Provo,
UT
Were Small farming communities with
colleges Became Rapidly growing business and
tech centers Why? Because of investments in
faculty and research infrastructure
Research laboratory
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Ying Fang, Research Assistant Professor

• Fang, Y., et al. National Pork Board. 2005 to
  2006. 46,000.
• Fang, Y., et al. USDA NRI PRRSV Integrated.  2005
  to 2006.  134,263.
• Fang, Y.  2005 to 2007.  USDA NRI SEED Grant
  Program.  100,000.
• Rowland, R.R.R. and Y. Fang.  2005 to 2006. 
  NIH-Midwest Regional Center of Excellence for
  Biodefense and Emerging Infectious Disease
  Research.  50,000.
• Neiger, B and Y. Fang. Summer, 2005.  Joseph F.
  Nelson Undergraduate Research Mentorship. 
  3,000.
• Total awards 333,263

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Feng Li, Associate Professor
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Questions?
Our mission is to foster research leading to
the development of novel therapeutic and
diagnostic technologies for infectious disease
in humans and domestic animals
PCR Testing for PRRS Virus, SDSU