T Cell Subsets

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T Cell Subsets
MHC Class II MHC Class I Peptide Peptide
Recognizes
TCR
TCR
CD4
CD8
CD3
CD3
T Helper Cell
T Cytotoxic Cell
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Antigen Processing and Presentation to T
Lymphocytes
Lecture 7
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Immune Responses are initiated in the Peripheral
lymphoid organs
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Dendritic Cell Migration and Antigen Presentation
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• How do antigenic peptides end up binding to MHC?
• What determines whether Ag. Is presented by MHC I
  or II?
• How can you target CD4 vs. CD8 T Cells?
• Physiological Significance

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Bacteria Candida Helminths (Worms)
Mycobacteria Salmonella Leishmania Trypanosoma His
toplasma Yersinia pestis
Viruses Listeria Chlamydia sps. Rickettsia sps.
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Vesicular
Cytosolic
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Exogenous/Endocytic Pathway
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Virus
Endogenous/cytosolic Pathway
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Cell Biology of Antigen Processing
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Antigen Presentation to CD8 T Cells
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Which cells can present antigen to CD8 T cells?
And Why?

• All nucleated cells

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Endogenous/Cytosolic Pathway
MHC I Pathway of Processing of Cytosolic Proteins
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Antigen Presentation to CD4 T Cells
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Which cells can present antigen to CD4 T Cells?
And Why?Professional Antigen Presenting
Cells Dendritic Cells Macrophages B cells
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Exogenous/Endocytic Pathway
Invariant Chain
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Antigen Presentation by Macrophage
Macrophage
T Cell
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Numerous T Cells Interacting with a Single
Macrophage
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Physiologic Significance of MHC II-Associated
Antigen Presentation
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Bacteria Candida Helminths (Worms)
Mycobacteria Salmonella Leishmania Trypanosoma His
toplasma Yersinia pestis
Viruses Listeria Chlamydia sps. Rickettsia sps.
CD4 T Cells
CD8 T Cells
CD4 T Cells