Diffusion Tensor Imaging in Bipolar Disorder

1
Diffusion Tensor Imaging in Bipolar Disorder

• Preliminary study (BPD, HS, N 9 per group)
• Prefrontal/periventricular regions of interest
  (ROI)
• Examined fractional anisotropy (FA) and trace
  apparent diffusion coefficient (TADC)
• FA significantly differed between groups TADC no
  difference between groups
• Conclusions
• FA but not TADC differences
• Suggest loss of axonal bundle coherence. This
  loss may contribute to the prefrontal cortical
  pathology in bipolar patients

White matter fractional anisotropy ROI BPD HS
p d 15 mm above AC 0.22 (.04) 0.25
(.04) .21 0.7 20 mm above AC 0.20 (.04) 0.23
(.03) .11 0.8 25 mm above AC 0.18 (.03) 0.22
(.04) .04 1.0 30 mm above AC 0.18 (.02) 0.22
(.03) .01 1.3 Total 0.78 (.12) 0.91 (.12) .05 1.0
Adler C, et al. Bipolar Disord.
20046(3)197-203.