NEUROSCIENCE INSTITUTE AT STANFORD (NIS)

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NEUROSCIENCE INSTITUTE AT STANFORD (NIS)
School of Medicine Retreat Jan. 29-31, 2004
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NEUROSCIENCE INSTITUTE

• Vision A new culture for neuroscience, involving
  scientists and clinicians, that motivates and
  supports fundamental neuroscience research and
  that translates discoveries into enhanced care
  for patients with disorders of the nervous system.

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To Integrate-To Translate-To Educate
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To Integrate
-across disciplines
-scientists and clinicians
-professionals and advocates
-across academic institutions
-academia, industry, government
NIS
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NIS

• To Translate

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Translational ResearchA Proposed Definition
The process of applying ideas, insights, and
discoveries generated through basic scientific
inquiry to the treatment or prevention of human
disease AND The process of taking insights
and ideas developed through the study of human
disease to generate new scientific insights.
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Translating Research Advances in the NIS
Breaking Down Barriers Through Integration of
Efforts
Science
Cognition

• Development
• Clinical trials
• Industry

• Delivery
• Health Care

Neuronal systems
Neurons
Genes
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Elements of Translational Research

• Basic investigation
• Disease-oriented research
• Patient-oriented research
• Clinical trials
• Population research

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NIS

• To Educate
• -the next generation of neuroscience leaders
• -young members of the faculty
• -scientists in training
• -medical students, through a new Scholarly
  Track
• -residents, through innovations in training

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NIS

• Mission To create this new culture, the
  Institute will -
• Establish an interdisciplinary environment
• Encourage the interaction of basic scientists,
  clinician-researchers and clinicians
• encourage the development of new research
  programs which capture the interest of both basic
  science and clinical faculty
• Support and enhance fundamental discovery,
  including studies of disease pathogenesis

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NIS

• Mission (continued)
• Support clinical research
• Encourage outstanding investigators at other
  institutions to join the effort
• Apply discoveries to the care of patients
• Work with industry to speed translation
• Create new training vehicles
• Enhance fundraising for neuroscience
• Build a home for the Institute

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NIS

• Whats new
• A new culture for neuroscience
• A new method for developing, supporting, and
  translating research
• A new way of enhancing the work of both basic
  science and clinical faculty
• A new opportunity to serve our patients
• A new message for donors we are rededicating
  our efforts to the service of those with
  disorders of the nervous system

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NIS

• An engine for neuroscience discovery and
  translation

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NIS

• Overview
• Neuroscience defining the discipline
• Neuroscience at Stanford defining the community
• NIS defining the plan
• NIS the expectation

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Neuroscience

• Defining the discipline
• Among the most exciting and vital
• Highly interdisciplinary
• all levels of biological organization from
  genes to cells to circuits to behavior
• from fundamental discovery through clinical care
• Enormous potential for enhancing the lives of
  patients with neurological and mental disorders

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Neuroscience

• Challenges
• To develop the tools and concepts needed to
  discover the complex cellular and circuit
  properties inherent in brain function
• To build research programs that effectively
  integrate across levels of analysis
• To define disease mechanisms at the molecular,
  cellular and systems levels
• To deliver on the promise of translation
• To prepare for the next generation of discovery

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Neuroscience

• Pursuing the objectives of modern neuroscience,
  especially those involving translation, demands
  new ways of thinking together and working
  together and new methods to support collaboration

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Neuroscience at Stanford

• Meeting the challenges
• A neuroscience community with a strong and
  diverse faculty that engages in technical
  innovation
• Establishing a collaborative, interdisciplinary
  environment that values both fundamental and
  clinical neuroscience discovery
• Building a culture that endeavors to both study
  and treat diseases of the nervous system
• Committed to training the next generation of
  leaders in neuroscience

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Neuroscience at Stanford

• A distinguished community
• -140 faculty, 17departments,
• 3 schools
• -Members of the NAS (10), IOM (4), Royal Society
  (2)
• -Nationally and internationally recognized for
  basic science and clinical contributions
• -Outstanding graduate program - 1 in
  effectiveness of graduate program by NRC

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A community with diverse interests and activities

• -working at all levels of nervous system
  organization from gene to behavior
• -working closely with the School and the
  Hospitals
• -active in basic and clinical research
• -providing outstanding clinical care
• -teaching at all levels
• -undergraduate
• -graduate student and postdoctoral fellow
• -medical student, resident and fellow

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A united community
SBRC NIS
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A community committed to translation
Center for Research and Treatment of Down Syndrome
Investigators Robert Malenka, Craig Garner,
Irving Weissman, Barbara Sommer, Allan Reiss,
Dick Tsien, William Mobley Abnormal Synaptic
Structure and Function in Down Syndrome
Elucidating Genetic, Molecular and Cellular
Mechanisms
Science
Cognition

• Development
• Clinical trials
• Industry

• Delivery
• Health Care

Neuronal systems
Neurons
Genes
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Center for Research and Treatment
Of Down Syndrome

• Clinical
• Program

Science
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A community committed to translation

• Developmental Motor Disorders Program
• -Terry Sanger, Scott Delp, Krishna Chenoy
• Helen Bronte-Stewart, Gary Heit
• - Basic and clinical research
• - Drives LPCH clinical program development
• - Collaborations with UTSW and Hopkins
• Stroke Center
• - Greg Albers, Gary Steinberg, Dave Tong,
• Mimi Yenari, Michael Marks, Michael Moseley,
• Pak Chan, Robert Sapolsky
• - Basic and clinical research and clinical
  care
• - Drives Stanford Hospital clinical program
  development

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NIS The Design
NIS
Cores
Outreach
Theme Groups
Training
Working Groups
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NIS

• Working Groups
• -for either fundamental or disease-related topics
• -define the state of the field
• -point to the gaps in understanding that inhibit
  progress
• -apply resources to fill those gaps
• -accelerate the development of new tools,
  concepts
• -accelerate translation of ideas to clinical care

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NIS

• Operating Principles-
• 1. The Institute exists to support the work of
  the faculty.
• 2. It does so, in part, by supporting the
  departments in which the faculty reside.
• 3. It does not compete with departments for
  space, money or billets.

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NIS

• Operating Principles-
• 4. Instead, the Institute
• - raises money, and gives it to the departments
• - secures space, and gives it to the departments
• - finds billets, and makes them available to
  departments
• 5. The Institutes infrastructure is small.
• 6. Institute operations will be supported by
  fundraising and by faculty support for services
  provided.

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NIS The Expectation
Future
Now
Basic
Interface
Clinical
Research
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To Integrate-To Translate-To Educate