AgeRelated Changes

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Age-Related Changes

• Is Aging a Disease ?

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Age Related Changes vs. Disease
View of geriatrics Aging is the sum of diseases
to which we eventually succumb But Aging
occurs in the absence of disease Gerontological
Viewpoint Process of Aging is separate from
age-related pathologies
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Age Related Pathologies
Prevalence of pathology increases with
age Incidence- the number of newly diagnosed
patients in a particular year / 100,000 (best
used for acute disease) Prevalence- total number
of patients at any one time / 100,000 (best
used for chronic diseases)
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Acute vs. Chronic Disease

• Acute disease - lasts a short time
• incidence a better measure
• frequency decreases with age

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Acute vs. Chronic Disease

• Chronic Disease - lasts a long time
• prevalence a better measure
• frequency increases with age

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Age Related vs. Age Dependent
Age Related frequency increases with
age (abnormal aging) Age Dependent inevitable
part of aging (normal aging) Must be a reason
for abnormal aging connection between aging
and disease ?
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Age Dependent Changes
(Inevitable part of aging)
Unless your Ronald Reagan
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Age Related Diseases

• Disease results as a consequence of dysfunction
  due to aging
• Cellular, molecular and genetic studies often
  reveal
• underlying cause (precondition).

e.g. arteriosclerosis
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Biomarkers as a Measure of Aging
Age-Dependent Changes are best predictors Remembe
r rates of aging vary with individual and
system. Test Success of Interventions A measure
of functional age
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Characteristics of a Biomarker
1. Rate of change of biomarker should reflect
rate of aging 2. Biomarker should monitor a
basic, important process 3. Test non-invasive,
easy to perform 4. Reproducible, maximum change
with time, min. variability 5. Effective
predictor of life span
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