Houston Technology Forum Biotechnology

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Houston Technology ForumBiotechnology

• John Mendelsohn, M.D.
• President
• The University of TexasM. D. Anderson Cancer
  Center

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Growth in Technology

• Information Technology
• Biotechnology
• Nanotechnology
• Interactions

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10 Leading Causes ofDeath (U.S.A.)

• 1900
• 1. Pneumonia, influenza
• 2. Tuberculosis
• 3. Diarrhea, enteritis
• 8. Cancer

• 2000
• 1. Heart disease
• 2. Cancer
• 3. Stroke
• 5. Pneumonia, influenza

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Genes and Disease
The products of mutated or malfunctioning genes
are the causes of the majority of deaths from
human diseases today. These gene abnormalities
may be hereditary, or acquired during a lifetime.

• Human genome project
• Functional genomics
• New targeted therapies
• New targeted tests for early diagnosis
• New targets for prevention

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Changed Paradigms

• Old
• Dx Cancer of the breast
• Rx Surgery, radiation, chemotherapy

• New
• 4 gene abnormalities p53, EGFr, Bcl2, VEGF
• Therapies acting on the4 gene targets added

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Changed Paradigms

• Prevention and early detection of cancer
• Current standard screening and changed
  habitscould reduce cancer deaths 50
• Genetic testing for inherited gene abnormalities
• Sampling of cells obtained from body
  secretionsfor presence of acquired gene
  abnormalities
• Chemoprevention Retinoids, Tamoxifen, Celebrex

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Example of New Paradigm

• Chronic Myelocytic Leukemia (CML)
• Basic research (1960-1985) in CML a chromosome
  rearrangement creates an abnormal gene,
  bcr-abl,which produces a specific enzyme.
• Drug development (1987-1997) screening for an
  inhibitor specific for this enzyme.
• Clinical trials (1998-2000) demonstrates
  efficacyin CML.
• Outcome (2001) FDA approved Gleevec, May 2001.

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Strategy Texas Biotech Economic Cluster

• 1. Life science research Strong--1.0 billion
  per year
• Texas Medical Center
• Universities Texas AM, TSU, U of H, Rice, UT,
  etc.
• NASA-Johnson Space Center
• 2. Clinical patient care Global leader
• 3. Research tech transfer Growing
• 4. Venture capital Growing rapidly
• 5. Business start-up support Strong
• 6. Biotech campus and affordable lab/office
  space Missing
• Southeast Texas BioTechnology Park Proposed

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Southeast Texas Biotechology Economic Cluster

• Multi-Disciplinary Life Science
  Discoveries. Pre-eminent
• Patient Care Throughput Global Leader
• Tech Transfer Programs.. Developing
• Entrepreneurship. Refocus to Biotech
• Capital.. ...Growing
• Facilities... ..Biotech Corridor - Park

Southeast Texas Biotech Corridor College
Station-Houston-Galveston University--Medical--NAS
A
Southeast Texas BioTechnology Park
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Texas Untapped Potential

• City Research s/yr New Companies/yr
• Houston gt1.0 billion 5
• Boston 1.6 billion 50
• San Diego 0.4 billion 72
• Silicon Valley 0.7 billion 97
• Source McKinsey Co.

Southeast Texas BioTechnology Park--Development
and Commercialization of Life Science Technologies
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Example San Diego

• 1963 first academic biomedical institution,
  Salk, followed by Scripps, UCSD
• 1977 first biotech company
• 1980 development of research park space near
  La Jolla academic institutions and Gulf Atomic
• 1985 UCSD Connect
• 2001 over 240 biotech and information
  technology companies

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Planning the Southeast Texas Biotechnology Park
Organizations andSupporters Houston Minority
Business Council Houston Technology Center City
of Houston Greater Houston Partnership Harris
County METRO Texas Medical Center

• Institutions
• Baylor
• Memorial Hermann
• Methodist
• NASAJohnson Space Center
• Rice
• St. Lukes
• Texas AM
• Texas Heart Institute
• TSU
• TIRR
• U of H
• UTHSC-Houston
• UTMDACC
• UTMB-Galveston

Corporations Browne Penland McGregorStephens
Architects Cogene Biotech Ventures Enron Gilbane
Building Company Introgen Therapeutics JP
MorganChase Texas John E. Walsh, Jr. Locke
Liddell Sapp Reliant Energy Southwestern Bell
Telephone Sterling Bank Tanox Trammell Crow
Company Turner Collie Braden W. J. Alexander
Associates
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Southeast Texas Biotechnology Park
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Southeast Texas Biotechnology Park

• Goal to establish facilities to develop and
  commercialize life science technologies
• Up to 64 acres, 15 buildings, 2 million s.f.
• Coalition of medical institutions, universities
  and the public sector
• Significant economic benefits for Houston and
  Texas

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Southeast Texas Biotechnology Park

• Economic benefits
• 23,000 new jobs
• 1.5 billion annual gross state product
• 900 million annual personal income
• State and regional tax revenues

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Southeast Texas Biotechnology Park

• Projected cost is 633 M over a 20-year
  development phase Private Sector 568 M
  (90) Local Government 45 M (7) State
  Funding 20 M (3)

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Partnering in High TechBiomedical Research

• Structural and computational biology Baylor,
  UTHSC, Rice, UTMDACC, U of H, UTMB, AM (Gulf
  Coast Consortium)
• Bioengineering UTMDACC/UT Austin (biomedical
  engineering) UTMDACC/Rice (tissue engineering)
• Pharmacology UTMDACC/TSU (genetics/addiction)

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