Participation of CVMP members in conferences and meetings with commercial purposes

1
Dr. Gérard Moulin Dr Catherine Lambert OIE,
AFSSA/ANMV Collaborating Centre on Veterinary
medicinal products BP 90203 - 35302 FOUGERES
CEDEX, FRANCE g.moulin_at_anmv.afssa.fr
International approach for veterinary medicinal
products OIE
and Codex alimentarius
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International approach for veterinary medicinal
products OIE and Codex alimentarius

• Introduction
• OIE activities related to VMP
• Codex activities
• Cooperation between Codex and OIE
• Residues in food from animal origin
• Antimicrobial resistance
• Conclusion

3
International approach for veterinary medicinal
products OIE and Codex alimentarius
Benefits
Risks

• Animal health and welfare
• Human nutrition
• Economic development

• Risk for animals
• Risks for humans
• Risks for the environment

• 1924 OIE, 1945 FAO, 1948 WHO

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WTO Agreement

• Agreement on the Application of Sanitary and
  Phytosanitary Measures (SPS Agreement)
• The SPS Agreement calls on countries to harmonize
  their national standards with international
  standards, guidelines or recommendations
  (Article 3.1).
• international standards, guidelines or
  recommendations (Annex A).
• Codex Standards for food safety
• OIE for animal health and zoonoses
• IPPC for plant health
• Agreement on Technical Barriers to Trade (TBT
  Agreement)
• The TBT Agreement calls on countries to use
  relevant international standards when they exist
  (Article 2.4).

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OIE's WTO mandate (cont.)
Codex Joint FAO/WHO Codex Alimentarius
Commission OIE World Organization for Animal
Health IPPC International Plant Protection
Convention (FAO)
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• an intergovernmental organisation
• founded in 1924 by 28 countries
• created before the U.N.

172 Member Countries
Common name adopted by the International
Committee on May 2003
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The 6 Objectives of the OIE

• ANIMAL HEALTH INFORMATION
• to ensure transparency in the global animal
  disease and zoonosis situation
• to collect, analyse and disseminate scientific
  veterinary information
• ACTIVITIES OF VETERINARY SERVICES
• to provide expertise and encourage international
  solidarity in the control of animal diseases
• to improve the legal framework and resources of
  national Veterinary Services
• INTERNATIONAL STANDARD
• within its WTO mandate, to safeguard world trade
  by publishing health standards for international
  trade in animals and animal products
• to provide a better guarantee of the safety of
  food of animal origin,
• and to promote animal welfare, through a
  science-based approach

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INTERNATIONAL COMMITTEE Administrative Commission
Director General
Specialist Commissions Code, Laboratories,Aquati
c animals, Scientific
Regional Commissions Africa, Americas, Europe,
Asia- Far East and Oceania, Middle East
Central Bureau
International Trade Department
Administrative and Management Systems Department
CollaboratingCentres ReferenceLaboratories
Ad hoc Groups Working Groups
Scientific and Technical Department
Regional Activities Department
Animal Health Information Department
Publications Department
Regional Representations
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Specialist Commissions (cont.)
Terrestrial Animal Health Standards Commission
"Code Commission"
Scientific Commission for Animal
Diseases"Scientific Commission"
Biological Standards Commission"Laboratories
Commission"
Aquatic Animal Health Standards Commission
"Aquatic Animals Commission"
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OIE International Standards
Terrestrial Animal Health Code mammals, birds
and bees
Aquatic Animal Health Code fish, molluscs and
crustaceans
Manual of Diagnostic Tests and Vaccines for
Terrestrial Animals
Manual of Diagnostic Tests for Aquatic Animals
available on the OIE Website
http//www.oie.int
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Working Groups
Wildlife Diseases
Animal Production Food Safety
Animal Welfare
Adhoc WG on antimicrobial resistance
Other
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Collaborating Centres

• Expert Centres on horizontal subjects, for the
  OIE and Member Countries
• Assist in the elaboration of procedures to
  harmonise animal disease regulations /
  international standards
• Coordinate collaborative studies
• Provide technical training
• Organise and host scientific meetings for the OIE

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AFSSA-ANMV OIE Collaborating centre role
The ANMV is the French Agency for Veterinary
Medicinal Product, Responsibilities in
assessment, Authorisation, Monitoring, Control,
Inspections ANMV is the OIE collaborating centre
for VMP
Fougères

• INTERNATIONAL HARMONISATION
• - OIE (standards methods registration
  of diagnostic assays)
• - Represent OIE for CODEX meeting
  related to VMP
• - Participate to WHO/FAO/OIE workshop, expert
  groups on VMP - Represent OIE to VICH
• - Established under the auspices of the OIE
• - Member of the Steering Committee
• RESEARCH and EXPERTISE
• Antimicrobial resistance/Benefit/R
  isk Assessment
• Pharmaceutical regulation
• TECHNICAL ASSISTANCE
• Bilateral and multilateral cooperation and
  assistance
• to OIE member countries (especially
  developing countries)
• UEMOA
• Twinning

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About Codex Alimentarius

• CODEX ALIMENTARIUS is latin for food code
• The Codex Alimentarius is a collection of food
  standards, guidelines and codes of practice
  developed by the Codex Alimentarius Commission
• June/July 1963 First Session of the Codex
  Alimentarius
• Currently 175 Member countries and One Member
  Organization (EC)

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Codex Alimentarius CommissionMandate

• To protect the health of consumers
• To ensure fair practices in international food
  trade
• To coordinate all food standardization work done
  by international organizations

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Codex Alimentarius CommissionWork organization

• Work is based on independent scientific advice
  provided by FAO/WHO in accordance with Risk
  Analysis principles
• Consensus whenever possible to ensure broad
  acceptance of standards - Votes are possible but
  rare
• Frequency Committees/ task forces every 12 to
  24 months - Executive Committee twice annually -
  Commission annually

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Codex organizational chart
CODEX ALIMENTARIUS COMMISSION
Executive Committee
Secretariat
Regional Coordinating Committees
Commodity Committees
General Subject Committees
Africa (Morocco)
Latin America and the Caribbean (Argentina)
General Principles (France)
Methods of Analysis and Sampling (Hungary)
active
Milk and Milk Products (New Zealand)
Processed Fruits and Vegetables (USA)
Asia (Republic of Korea)
North America and the Southwest Pacific (Samoa)
Food Additives (China)
Pesticide Residues (China)
Fish and Fishery Products (Norway)
Fresh Fruit and Vegetables (Mexico)
Contaminants in Foods (Netherlands)
Residues of Veterinary Drugs in Foods (USA)
Europe (Switzerland)
Near East (Jordan)
Fats and Oils (United Kingdom)
Food Hygiene (USA)
Food Labelling (Canada)
ad hoc Intergovernmental Task Forces
adjourned
Meat Hygiene (New Zealand)
Sugars (United Kingdom)
Nutrition and Foods for Special Dietary
Uses (Germany)

• Food Import and Export Inspection and
  Certification Systems (Australia)

Biotechnology (Japan)
Antimicrobial Resistance (Republic of Korea)
Cereals, Pulses and Legumes (USA)
Vegetable Proteins (Canada)
Processing and Handling of Quick Frozen
Foods (Thailand)
Natural Mineral Waters (Switzerland)
Cocoa Products and Chocolate (Switzerland)
dissolved
Fruit and Vegetable Juices (Brazil)
Animal Feeding (Denmark)
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Codex organizational chart
CODEX ALIMENTARIUS COMMISSION
Executive Committee
Secretariat
General Subject Committees
General Principles (France)
Residues of Veterinary Drugs in Foods (USA)
ad hoc Intergovernmental Task Forces
Antimicrobial Resistance (Republic of Korea)
Activities focussed on main risks linked with the
use of VMP
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COLLABORATION BETWEEN
AND
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Collaboration between OIE and Codex alimentarius

• No formal agreement with Codex
• Separate Agreement between OIE and FAO and OIE
  and WHO (2004)
• Current Status of OIE in Codex Observer
• On going discussion to strengthen the link with
  Codex (CAC July 2007, Alinorm 05/28/41)

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CCRVDF

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CCRVDF
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JECFA RISK ASSESSMENT

• The Joint FAO/WHO Expert Committee on Food
  Additives (JECFA) is an international expert
  scientific committee that is administered jointly
  by the FAO) and WHO. It has been meeting since
  1956, initially to evaluate the safety of food
  additives. Its work now also includes the
  evaluation of contaminants, naturally occurring
  toxicants and residues of veterinary drugs in
  food.
• To date, JECFA has evaluated more than 1500 food
  additives, approximately 40 contaminants and
  naturally occurring toxicants, and residues of
  approximately 90 veterinary drugs. The Committee
  has also developed principles for the safety
  assessment of chemicals in food that are
  consistent with current thinking on risk
  assessment and take account of recent
  developments in toxicology and other relevant
  scientific areas such as microbiology,
  biotechnology, exposure assessment, food
  chemistry including analytical chemistry and
  assessment of maximum residue limits for
  veterinary drugs.
• JECFA normally meets twice a year with individual
  agendas covering either (i) food additives,
  contaminants and naturally occurring toxicants in
  food or (ii) residues of veterinary drugs in
  food.

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Antimicrobial resistance activities

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OIE antimicrobial resistance related activities

• OIE adhoc group on antimicrobial resistance

Five guidelines adopted by the OIE international
session and published as standards (2003/2004)

• Terrestrial animal health code Section - 3.9
  antimicrobial resistance
• Appendix 3.9.1 Guidelines for the harmonisation
  of antimicrobial resistance surveillance and
  monitoring programmes
• Appendix 3.9.2 Guidelines for the monitoring of
  the quantities of antimicrobials used in animal
  husbandry
• Appendix 3.9.3 Guidelines for the responsible
  and prudent use of antimicrobial agents in
  veterinary medicine
• Appendix 3.9.4 Risk assessment for antimicrobial
  resistance arising from the use of antimicrobials
  in animals

• Manual of Diagnostic Tests and vaccines for
  Terrestrial Animals
• Laboratory methodologies for bacterial
  antimicrobial susceptibility testing

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OIE antimicrobial resistance related activities
International meetings

• FAO/WHO/OIE experts consultation (Geneva) on non
  human antimicrobial usage and antimicrobial
  resistance
• FAO/WHO/OIE experts consultation (Oslo) on non
  human antimicrobial usage and antimicrobial
  resistance
• Participation to the WHO expert meeting on CIA
  (Canberra)
• FAO/WHO/OIE Expert Consultation on Antimicrobial
  Use in Aquaculture and Antimicrobial Resistance
  (Seoul)
• Participation to the WHO meeting on CIA
  (Copenhagen)
• Participation to the Codex Task Force on AMR
  (Seoul)
• FAO/WHO/OIE expert consultation on CIA and VCIA
  (Roma)

2003
2004
2005
2006
2007
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Codex task Force
http//codextfamr.kfda.go.kr
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Codex task Force - Results

• Creation of Three Working groups
• Risk assessment (Chair Canada)
• Risk profile (Chair US)
• Risk management (Chair DK/FR)
• Recommendation that risk management should be
  adapted to level of development of countries
• Meeting of the three WG (May 2008, Brussels)

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ANTIMICROBIAL WORK IN OIEList of critically
important antimicrobial agents
VCIA

• After 2 joint FAO-WHO-OIE experts consultation
  (Geneva 2003, Oslo 2004) on non human
  antimicrobial usage and antimicrobial resistance
• It was recommended that the concept of critically
  important classes of antimicrobial agents, both
  in human and veterinary medicine should be
  developed

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List of veterinary critically important
antimicrobial agents

• In May 2006, OIE International committee adopted
  Resolution n XXXIII asking to refine the list
• The OIE Ad hoc group on Antimicrobial resistance
  met in September 2006 and proposed a new list
• In May 2007 OIE International committee adopted
  the List of Antimicrobials of Veterinary
  Importance (Resolution n XXVII)
• The list can be found at
• http//www.oie.int/downld/Antimicrobials/OIE_list_
  antimicrobials.pdf

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Rome meeting November 2007
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CONCLUSION

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Conclusion

• International standards are useful tools for
  countries to be used
• Public health
• International trade
• OIE cooperate actively with Codex in the field of
  Veterinary medicine particularly in CCRVDF and in
  Codex Task force on antimicrobial resistance
• The ongoing cooperation between FAO, WHO, Codex
  and OIE is essential,
• OIE Working Group on Food Safety (created to
  coordinate and manage the animal production food
  safety activities) will continue to work for a
  strengthened cooperation with Codex.

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No Resistant Bacteria
No Residues
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