BioPhotonics

1
BioPhotonics Physics and Oriental Medicine

• Han C. Ryoo, Ph.D.
• Richard Beard. Ph.D.
• School of Biomedical Engineering, Science and
  Health Systems
• Drexel University, PA 19104
• (Details can not be provided for IP protection)

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Objectives

• Improve Healing Process in Diabetic Patients
• Improve Sensitivity of Surface Electrodes
• Developing Non-invasive Acupuncture Therapy

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Background

• Polymorphonuclear leukocytes, PMNs and
  mononuclear leukocytes, MNLs, have had their
  migration investigated in vitro over that last 2
  decades or more. The influence of magnetic
  fields, the effect of photons from light emitting
  diodes (LEDs) at different wavelengths and
  intensities have been studied, and the use of
  electromagnetic stimulation at different
  dielectric relaxation frequencies have been
  applied in vitro.
•  
• The comparison of the relative value of the
  distance to cell migration under stimulation and
  without stimulation is recorded as cytokinetics
  index, K.I., which is a measure of the
  cytokinesis which is the progress of cell
  movement in which the migration is enhanced by
  substances in the cell environment irrespective
  of a concentration gradient. Cytotaxis is the
  directional movement of the cells along a
  chemical gradient formed by chemoattractant while
  cytokinesis is the process of cell movement in
  which the migration is enhanced by substances in
  the cell environment irrespective of a
  concentration gradient (random migration).

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Background (Cont..)

• PMNs comprise 58 and MNLs approximately 38 of
  normal blood count. MNLs comprise about 10
  monocytes and 90 of lympocytes while PMN peak
  emigration occurs within the first 6 hours after
  an assault on the body. MNLs predominate after 12
  hours. Applications of this enhanced migration
  will be investigated relative to wound healing in
  diabetic patients, enhanced electrode
  sensitivity and surface acupuncture therapy.

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Approaches

• Biomedical Optics Physics
• LEDS with different wavelengths
• Magnets (Permanent, Helmholtz Coil) with
  different Gauss Levels
• Optical and Magnetic Interaction of Biological
  Tissues
• Measure Skin Impedance using Invasive
  (Acupuncture Needles) and Non-invasive (Surface)
  Electrodes
• Input Current lt 5mA, Frequency Ranges
  (500 hz 10 Mhz)

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Equipments Devices

• Impedance Analyzer
• Power Supply
• Gauss Meter
• Helmholtz Coils (Cored, Coreless)
• Permanent Magnets
• Acupuncture Needles
• LEDs (Red, Green, Yellow, Orange)
• Alcohol, wires, batteries and others.

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New Electrode Design for Improved Sensitivity and
Healing process
New Surface Electrode Design
LED Patches for diabetic wound
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Magnetic Optical Interaction on Phantom Tissue
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In-Vivo Measurement of Skin Impedance
Weak Gauss (lt12 G)
Strong Gauss (gt12 G), Dr. Beard was protected by
Metallic Shield. (Implanted Defibrillator lt 9G )
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Impedance Change by Acupuncture Needle
Frequency Ranges 500 Hz 10 MHz Oscillator
Voltage 5 mV
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Electrocardiogram (ECG) by IQ Impedance System
with 100 kHz and 5mA
The peak-to-peak of ECG signal was improved about
10 on the average (Lead II Configuration)
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In Progress .