Endocrinology 4 - PowerPoint PPT Presentation

1 / 17
About This Presentation
Title:

Endocrinology 4

Description:

Can induce production of other cytokines as well as cortisol ... Hypertension. Ulcers. Psychogenic dwarfism. Anovulatory, impotence. Impaired disease resistance ... – PowerPoint PPT presentation

Number of Views:41
Avg rating:3.0/5.0
Slides: 18
Provided by: jpsl
Category:

less

Transcript and Presenter's Notes

Title: Endocrinology 4


1
Endocrinology 4
  • Immune Endocrine Interactions

2
Immune System Review
  • Innate
  • Adaptive

3
(No Transcript)
4
(No Transcript)
5
(No Transcript)
6
(No Transcript)
7
(No Transcript)
8
Cytokines
  • Chemokines
  • Chemotactic
  • Inflammatory
  • TNF etc
  • Anti-inflammatory
  • IL 6
  • Growth factors
  • Interferon

9
Cytokines Communication
  • Autocrine
  • Self
  • Paracrine
  • Neighbor
  • Juxtacrine
  • Specific neighbor
  • Endocrine
  • blood

10
Important Cytokines
  • Tumor necrosis factor
  • Pro-inflammatory
  • Mobilization of anti-microbial substances
  • Denial of TNF increases infections
  • Can induce production of other cytokines as well
    as cortisol
  • Can induce apoptosis in T-cells and tumor cells

11
Important Cytokines
  • Interleukin 10
  • Anti-inflammatory
  • Immunostimulatory
  • Production of B cells
  • Interleukin 6
  • Increased in response to variety of stresses
  • Acute phase proteins
  • Protease inhibitors
  • Microbial recognition proteins(C-reactive)
  • Cytokine antagonists
  • Activation of lipolysis

12
Stress Response
  • Stressor
  • Stress-response
  • Systems stimulated by stress
  • Hormonal
  • Cortisol
  • Endorphins
  • Sympathetic nervous system
  • Epinephrine
  • norepinephrine

13
Stress Response
  • Increases energy availability
  • Increased oxygen uptake
  • Changes in blood flow
  • Inhibition of non-essential systems
  • Decreased pain perception
  • Enhancement of memory and sensory function

14
Stress Response
  • Systems Inhibited by Stress
  • GnRH, FSH, LH
  • GH and somatomedins
  • Short term stress my increase GH in humans

15
Stress Response
  • Metabolic
  • Insulin inhibited
  • Glucagon, glucocorticoids, cathecholamines
    increase
  • Body becomes catabolic
  • Cardiovascular
  • HR, BP go up
  • Vasopressin goes up
  • Blood flow changes

16
Stress Response
  • Gastrointestinal
  • Gastric hormones decrease
  • Can stress make H. pylori infections worse?
  • Reproductive
  • Sex hormones drop
  • GnRH inhibited by endorphins and CRH
  • Implantation less likely because of diminished
    progesterone

17
Stress response Pathology
  • Catabolism
  • Increased CV tone
  • Suppression of digestion
  • Suppression of growth
  • Suppression of reproduction
  • Suppression of immunity
  • Fatigue, myopathy
  • Hypertension
  • Ulcers
  • Psychogenic dwarfism
  • Anovulatory, impotence
  • Impaired disease resistance
Write a Comment
User Comments (0)
About PowerShow.com