Eli Lilly

1
Eli Lilly

• Emily Keener
• Chemistry 280
• April 3, 2001

2
Facts and Figures

• Ninth largest drug company in the world
• Based in Indianapolis, Indiana
• Plants in 39 countries
• More than 31,000 employees worldwide
• 1999 net income - over 2.5 billion
• Research exceeds 1,783.6 million/year

3
1876 The Beginning

• Colonel Eli Lilly was frustrated with poorly
  prepared, ineffective medicines of the day
• Desired the creation of a new company with high
  standards
• Manufacture highest quality of pharmaceutical
  products
• Products only to be dispensed by suggestions of
  physicians
• Technology based on best sciences of the day

4
History

• 1876 Created company
• 1879 Developed gelatin coated pills
• 1880s Initiated pharmaceutical research
• 1923 Introduced first insulin product
• 1952 Isolated erythromycin
• 1960s Launched Cephalosporins
• 1974 Involved in DES litigation
• 1980s Used recombinant DNA technology

5
Products

• Axid for ulcer and heartburn treatment
• Evista for osteoporosis
• Gemzar for pancreatic and lung cancer
• Humatrope for growth hormone deficiency
• Humulin human insulin
• Humalog rapid acting insulin
• Prozac for depression, bulimia, and OCD
• Sarafem for premenstrual dysphoric disorder

6

• Used in treatment of depression, OCD, and bulemia
• Discovered in 1972
• Obtained FDA approval in 1987
• Balances neurotransmitters

Fluoxetine hydrochloride
7
Prozac
In Depression Problem with serotonin balance.
Normal Serotonin is released in space between
cells.
Prozac Serotonin uptake pump is blocked.
8
Humalog

• Contains non-disease producing strands of
  laboratory Escherichia coli
• Lowers blood sugar quickly because of high
  concentration
• Must be taken within 15 minutes of eating

9
Humatrope

• Polypeptide hormone of recombinant DNA
• Identical amino acid sequence to that of a human
  pituitary growth hormone
• Stimulates linear growth
• Tissue growth
• Protein metabolism
• Carbohydrate metabolism
• Lipid metabolism

10
Looking Ahead

• Lilly is currently partnering with other
  pharmaceutical powerhouses to collaborate in
  finding a cure for AIDS.
• The company is trying to halve the time-to-market
  period for new drugs which is currently about 13
  years.

11
QUESTIONS?