Principles of Immunology Autoimmunity 4/25/06

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Principles of ImmunologyAutoimmunity4/25/06
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Organs Specific Autoimmune Diseases

• Hashimotos thyroiditis
• DTH like response to thyroid Ags
• Ab to thyroglobulin
• Hypothyroidism
• Pernicious anemia
• Ab to gastric parietal cells
• Interferes with vitamin update
• Reduced RBCs

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Organs Specific Autoimmune Diseases

• Goodpastures syndrome
• Ab to Ag on basement membranes
• C activation
• Glomerulonephritis, pulmonary disease
• Type 1 diabetes
• Ab to beta cells of pancreas
• DTF reaction
• Cytokine induced damage

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Organs Specific Autoimmune Diseases

• Myasthenia gravis
• Ab to acetyl choline receptors
• Blocks muscle activation
• C activation and damage to muscle cells

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Systemic Autoimmune Disease

• SLE
• Ab to certain tissue antigens
• Vasculitis
• Diagnosis using anti nuclear antibodies
• MS
• Reaction to myelin sheath
• Viral component?

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Systemic Autoimmune Disease

• Rheumatoid arthritis
• IgM which is anti IgG
• Immune complexes
• Chronic inflammation

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Genetics vs. Environment

• HLA type
• Sequestered antigens

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CD4 Cells and Autoimmune Disease

• Transferable
• Anti CD4 Ab protective

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Mechanisms

• Release or expression of Ags
• Cross reacting Ags

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Therapies

• Cyclosporin
• Interferes with T cell development
• Anti-inflammatories