Isoniazid

1
Isoniazid

• Seizure
• Glutamic acid decarboxylase
• Coenzyme pyridoxamine
• No GABA formed
• AG metabolic acidosis
• Blocks conversion of lactate to pyruvate
• Hyperglycemia

2

• 22 y/o male asthmatic took some pills to kill
  himself and is comatose.
• BP 120/80 HR 110 RR 20 T 101
• Wheezing
• 7.36/22/250

3
Primary Metabolic AcidosisPrimary Metabolic
Alkalosis

• ASA
• Post-ictal
• Ibuprofen
• Xanthines
• Asthma
• Liver disease

4

• 24 y/o male intern on July 2 cannot handle the
  work and is found in the call room comatose.
• HR 75 BP 120/80 RR 16 T 98

5
Sedatives/Hypnotics

• Benzodiazepines
• Not
• Barbituates or opiates RR
• Meprobamate Fluctuating MSE
• Cyclic esters PE
• ETOH Smell
• Methaqualone Anti-ACH,EPS Hyperaccussis

6

• 50 y/o male with nebulous complaints, asking for
  something to help him sleep.
• You noticed that he has blisters on legs and
  trunk.

7
Bullae

• Barbituates Consider
• Meprobamate Pemphigus
• Ethyl chlorovinyl Drug rxn
• Diclofenac
• Not
• Skin poppers

8

• I have blurry vision and cannot focus my eyes.

9
Mydriatics

• Anticholinergics Nicotinic
• Antidepressants
• Antihistamines
• Sympathomimetics
• Crack eye or nebulizer
• Red top drops
• Eye disease

10
Miotics

• Opiates
• Clonidine
• Cholinergics
• Anticholinergics Muscarinic-rare
• Buspirone/olanzipine
• Neuroleptics
• Post-eye surgery
• Green/blue/yellow top drops
• Pontine hemorrhage

11

• 3 y/o BIBA unresponsive after eating 3 of
  grannys BP pills.
• HR 70 BP na RR 11
• Child responsive to deep stimulus and has
  pinpoint pupils

12

• 50 y/o hypertensive BIBA for syncope in church.
• HR 40 BP 90/60 RR 16

13
Bradycardia

• Clonidine
• Calcium channel blockers
• Beta-blockers
• Cardiac glycosides
• Opiates
• Cholinergics
• Cushing reflex
• Inferior wall MI
• Health

14

• On the first cold day of fall, a child BIBA
  comatose. Later, parents arrive with c/o HA and
  not feeling well, but are more concerned of
  childs status and what they are going to tell
  him when he wakes up as his dog has mysteriously
  died on the same day.

15
Hypothermia

• CO
• Sulfonylureas
• Phenothiazines
• Sedative/hypnotics
• Opiates
• ETOH

16

• 17 y/o female was just dumped by her boyfriend.
  Mother called EMS because she is breathing too
  fast.
• OE upset, anxious female

17
AG Metabolic Acidosis

• Methanol
• Uremia
• DKA
• Paraldehyde
• Iron, INH, Ibuprofen
• Lactic acidosis
• Ethylene glycol
• Salicylates
• Also CN,CO,theophylline,hydrocarbons

18
Hyperventilation

• Cholinergics Fever
• Theophylline Sepsis
• Cocaine Hypoxia
• AG metabolic acidosis Asthma
• PE
• Midbrain hemorrhage
• Anxiety

19

• Police bring in a crack head wandering on the
  Grand Concourse on July 4, confused and agitated.
• BP 150/105 HR110 RR 22 T 104

20
Hyperthermia

• Sympathomimetics
• Anticholinergics
• NMS
• Serotonin syndrome
• Arsenic
• LSD
• Ecstasy
• Heat stroke/exhuastion
• Thyriod Storm

21

• 22 y/o female found in a clubs bathroom
  comatose. Intubated on field without drugs.

22
Hypoventilation

• Opiates
• ETOH
• Isopropyl
• Clonidine
• Cholinergics (late)
• Botulism
• NMJ disorders
• Sedatives/hypnotics
• GHB

23

• 38 y/o male BIBA at the gym c/o weakness and had
  a syncopal event. He takes an antiepileptic agent
  and a new medicine for his back pain.
• Unremarkable exam.
• EKG shows widened QRS with QT 530 ms

24
Class IA Antiarrhythmics

• Quinidine, procainamide
• TCA
• Propoxyphene
• Methacarbamol, cyclobenzoprene
• Cocaine
• Phenothiazines
• Carbamazepine
• 2nd generation antihistamines

25

• 50 y/o female who just arrived from Mexico, c/o
  of being bitten by a scorpion which was in her
  coat pocket while she was reaching for her
  medication.
• She was also bitten 10 days ago by a skunk while
  running away from a snake after using IV drugs in
  her backyard.
• OE agitated and salivating copiously.

26
Sialorrhea

• Rabies
• Clozaril
• Metal fume fever
• Mercury
• Scorpion stings
• Crotalids
• Cholinergics
• Ketamine

27

• 20 y/o male returned from Dominican Republic c/o
  diarrhea. He has spent a month eating his
  grandmothers cooking, whose hygiene is dubious.
• HR 50 BP 120/80 RR 20 T 104

28
Fagets sign/Pel-Ebstien Fever

• Salmonella Yellow Fever
• Legionella
• Psittacosis
• Antineoplastic drugs
• Tumors
• Hepatomas/liver mets Myxoma
• Nephroma Lymphoma
• Sarcoma