Academic Centers Research Node of PECARN (

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Academic Centers Research Node of PECARN
(ACORN)

• Supported by Project U03 MC00001-01 from the
  Maternal and Child Health Bureau, Health
  Resources and Services Administration, Department
  of Health and Human Services

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Who We Are

• University of California, Davis Medical Center,
• University of California, Davis School of
  Medicine
• Childrens Hospital of Wisconsin,
• Medical College of Wisconsin
• Childrens Hospital of Philadelphia,
• University of Pennsylvania School of Medicine
• St. Louis Childrens Hospital,
• Washington University School of Medicine
• Primary Childrens Medical Center,
• University of Utah School of Medicine
• Childrens Hospital Medical Center,
• University of Cincinnati School of Medicine

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University of California, Davis Medical
CenterUniversity of California, Davis

• Nathan Kuppermann, MD, MPH
• Chair, Department of Emergency Medicine,
• Professor of Emergency Medicine/Pediatrics
• Emily Kim, MPH
• ACORN Node Administrator
• James Holmes Jr., MD, MPH
• Trauma Consultant
• Associate Professor of Emergency
  Medicine/Pediatrics

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Childrens Hospital of Wisconsin, Medical
College of Wisconsin

• Marc Gorelick, MD, MSCE
• Medical Director, Emergency Department,
• Professor of Pediatrics and Emergency Medicine

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Childrens Hospital of Philadelphia, University
of Pennsylvania

• Elizabeth Alpern, MD, MSCE
• Assistant Professor of Pediatrics
• Kathy Shaw, MD, MSCE
• Division Chief, Pediatric Emergency Medicine,
• Professor of Pediatrics
• Evaline Alessandrini, MD, MSCE
• Associate Professor of Pediatrics

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St. Louis Childrens Hospital, Washington
University in St. Louis School of Medicine

• David Jaffe, MD
• Medical Director of Emergency Services,
• Professor of Pediatrics
• Walton Schalick, MD, PhD
• Ethics Consultant
• Assistant Professor of Bioethics, Medical
  History, Pediatric
• Orthopedics Rehabilitation
• University of Wisconsin-Madison

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Primary Childrens Medical Center, University
of Utah

• Douglas Nelson, MD
• Professor of Pediatrics
• Associate Chief, Emergency Pediatric
  Medicine

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Cincinnati Childrens Hospital Medical Center,
University of Cincinnati College of Medicine

• Richard Ruddy, MD
• Director, Division of Emergency Medicine,
• Professor of Clinical Pediatrics

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Where We Are Located
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ACORN Organizational Structure
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Key Features of the ACORN Node

• Comprised of Three HEDA Cores
• Administrative
• Ethics/ Human Subjects
• Epidemiological/Biostatistics

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Key Features of the ACORN Node

• HEDA Cores
• Administrative
• Overall nodal organizational responsibility
• Oversee generation of nodal research priority
  list
• Oversee the conduct of nodal research
• Oversee intranodal, internodal communications
• Build partnerships with the MCHB/EMSC

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Key Features of the ACORN Node

• HEDA Cores
• Ethics / Human Subjects
• Insure the protection of human subjects
• Review ethical content of all nodal research by
  committee
• Advise nodal investigators regarding all ethical
  issues pertaining to nodal research prior to
  submission to PECARN
• Review IRB issues at nodal HEDAs and help
  coordinate activities which require cooperation
  between IRBs

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Key Features of the ACORN Node

• HEDA Cores
• Epidemiology / Biostatistics
• Review nodal research proposals and provide
  specific feedback to investigators on issues of
  study design, sources of bias and confounding,
  sample size and power, logistics and feasibility
• Assist in the development of surveys and other
  data collection instruments
• Assist with statistical analysis of completed
  nodal research, including multivariable
  statistical models and techniques for validation
• Assist with preparation of research presentations
  and manuscripts

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ACORN Proposal Generation Review Process
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ACORN Research

• Approved Projects
• Randomized Trial of Oral Dexamethasone in Acute
  Bronchiolitis
• PECARN Core Data Project (with CARN)
• Head Injury Project
• Cervical Spine Injury Project
• Intra-abdominal Injury Project
• Patient Safety Project (with CARN)
• Quality Measures Project

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Concluding Statement

• The ACORN Node of PECARN is committed to applying
  our strengths and expertise to the study of the
  prevention and treatment of acutely ill and
  injured children.
• We will forge strong collaborations with all
  other Nodes of PECARN and the MCHB/EMSC.
• We are confident that the strong commitment of
  all the Nodes of PECARN will insure the success
  of this novel and exciting network.