Antihistamines

1
Antihistamines

• End in
• -adine

2
Antihistamine

• Generic Desloratadine
• Brand Clarinex
• Indications Seasonal allergic rhinitis
• Adult Dosage 5 mg ORALLY once daily
• 6-11 years 2.5 mg once daily
• 12 months to 5 years 1.25 mg once daily
• Children 6-11 months 1 mg once daily

3
Desloratadine

• Adverse Effects Headache (14),
• CNS Fatigue (5)
• Gastrointestinal nausea (5) Xerostomia
• Musculoskeletal Myalgia
• Neurologic Dizziness, Somnolence
• Respiratory Pharyngitis
• Other Fatigue, Influenza-like illness
• Pregnancy Category C

4
Antihistamine

• Generic Cetirazine
• Brand Zyrtec
• Indications Seasonal allergic rhinitis1
• Adult Dosage 5-10 mg ORALLY once daily1
• Elderly 5 mg once daily
• Adverse Effects
• Gastrointestinal Xerostomia
• Neurologic Headache (11-14), Somnolence (14),
  Insomnia (9)
• Other Fatigue (6)
• Pregnancy Category B

5
Antihistamine

• Generic Fexofenadine
• Brand Allegra
• Indications Seasonal allergic rhinitis1
• Adult Dosage 60 mg ORALLY twice daily or 180 mg
  once daily with water
• Pediatric gt6 20 mg twice daily
• Safety and Efficacy in children lt6 years of age
  have not been established

6
Fexofenadine

• Adverse Effects
• Gastrointestinal Dyspepsia (1 - 5)
• Neurologic Dizziness, Headache (5-10),
  Somnolence
• Otic Otitis media
• Reproductive Dysmenorrhea
• Respiratory Upper respiratory infection
• Other Fatigue, Viral disease, Cold, flu
• Pregnancy Category D

7

• Notes
• Avoid Ethanol (may increase risk of sedation)
• Fruit juice may decrease bioavailability

8
Works Cited

• 1. Micromedex