INBRE RESEARCH PROGRAM

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INBRE RESEARCH PROGRAM
INTERACTION OF 3 PRIMARY RESEARCH UNIVERSITIES
BUILT ON COOPERATION RATHER THAN COMPETITION
THEMATIC INTERACTION OF REGENERATIVE MEDICINE
BUILD RESEARCH OPPORTUNITIES WITH UNDER- GRADUATE
INSTITUTIONS THROUGH DEVELOPMENT OF CORE
RESEARCH FACILITIES
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INBRE RESEARCH PROGRAM
CLEMSON UNIVERSITY-MATERIAL SCIENCE/BIOENGINEERING
UNIVERSITY OF SOUTH CAROLINA-DEVELOPMENTAL BIOLOGY
MEDICAL UNIVERSITY OF SOUTH CAROLINA-STEM CELL
BIOLOGY
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INBRE RESEARCH PROGRAM
REGENERATIVE MEDICINE
GENERATION OF NEW TISSUES AND ORGANS
DEVELOPMENT OF NEW APPROACHES TO WOUND HEALING
BASED ON PRINCIPLES OF DEVELOPMENTAL BIOLOGY
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INBRE RESEARCH PROGRAM
STRENGTHS
WELL ESTABLISHED PROGRAM AT CLEMSON AND MUSC
IN BIOENGINEERING AND MATERIAL SCIENCES
PROGRAM IN DEVELOPMENTAL BIOLOGY AT USC
AND STRONG ENGINEERING PROGRAM NEW
BIOENGINEERING PROGAM
CHAIRS IN REGENERATIVE MEDICINE AT MUSC, USC AND
CLEMSON
STATE WIDE COMMITMENT TO GROWTH
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INBRE RESEARCH PROGRAM
WEAKNESS
THREE SEPARATE PROGAMS WITH LITTLE COORDINATION
(COMPETITION FOR THE SAME DOLLARS)
CRITICAL MASS IN RESEARCH AREAS
INBRE AND COBRE WILL CHANGE THIS DYNAMIC
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INBRE RESEARCH PROGRAM
ROLE OF INBRE
INCREASE THE CRITICAL MASS IN COOPERATIVE PROGRAMS
PROMOTE WORKSHOPS THAT RAISE TECHNICAL
EXPERTISE, SHARE REAGENTS, AND ENHANCE
COMMUNICATION
SYMPOSIA TO PROMOTE NATIONAL/INTERNATIONAL VISIBIL
ITY
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INBRE RESEARCH PROGRAM
STATUS
SYMPOSIUM FOR THIS SPRING IS IN DEVELOPMENT TO BE
HELD AT CLEMSON
TENTATIVE AREAS OF EMPHASIS INCLUDE VASCULAR
BIOLOGY ARTIFICIAL MATRICES MARKERS OF
DIFFERENTIATION
CHAIRS IN REGENERATIVE MEDICINE SEARCH
COMMITTEES FORMED, OFFERS BEING MADE
COBRE RENEWAL WAS RECENTLY SUBMITTED
(HEY! WE JUST GOT THE BUDGET!)
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USC INBRE PROGRAM
DEVELOPMENT OF STRONG RESEARCH PROGRAM IN
REGENERATIVE MEDICINE/BIOMEDICAL ENGINEERING
BUILD CRITICAL FACULTY MASS
DEVELOP WORKSHOP IN APPLICATION OF IMAGING TO
RESEARCH
EDUCATIONAL PROGRAM IN BIOMEDICIAL
ENGINEERING APPROVED AT UNIVERSITY LEVEL,
SUBMITTED FOR STATE APPROVAL WITH SUPPORT FROM
CLEMSON AND MUSC
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USC INBRE PROGRAM
PROGRAMATIC GROWTH
SENIOR BIOENGINEERING FACULTY IDENTIFIED (NSF
PROGRAM) HIRING BEING NEGOTIATED
BIOMEDICAL ENGINEERING COMMITTEE IDENTIFIED AREAS
OF EMPHASIS FOR THE NEW PROGRAM
CARDIOVASCULAR BIOLOGY WOUND HEALIING
NEUROSCIENCES (BRAIN IMAGING)
PROVOST HAS COMMITTED 4 POSITIONS- SEARCH
COMMITTEE HAS BEEN FORMED, ADVERTISED,
RECRUITING BEGINS!
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USC INBRE PROGRAM
RESEARCH PROGRAM-TARGET FACULTY
IDENTIFY TARGET FACULTY FOR THEMATIC GROWTH
DEVELOP RESEARCH PROJECTS LIKELY TO LEAD TO
NATIONAL FUNDING
DEVELOP A SCIENTIST-MENTOR RELATIONSHIP
FORMULATE RESEARCH PROGRAM INCLUDING BUDGETS AND
DEADLINES FOR GRANT SUBMISSIONS.
(WEVE DONE ALL THIS STUFF)
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USC INBRE PROGRAM
TARGET FACULTY/MENTORS
SARAH BAXTER, MECHANICAL ENGINEERING
MENTOR EDIE GOLDSMITH, CELL BIOLOGY
JEFF BISCHOFF, MECHANICAL ENGINEERING
MENTOR WAYNE CARVER, CELL BIOLOGY
SUSSAN LESSNER, CELL BIOLOGY MENTOR
THOMAS BORG
TROY BAUDINO, CELL BIOLOGY MENTOR
FRANK BERGER, BIOLOGICAL SCIENCES
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USC INBRE PROGRAM
cMYC Regulation of Angiogenesis
TROY BAUDINO
Overall goal is to examine cMYC regulation of
growth factor expression
Examining the relationship of stromal cells,
tumor cells in the regulation of
VEGF. Cell-cell regulation by cadherins
Progress-one RO1 submitted, AHA grant to be
submitted on Jan. 1
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Cardiac Fibroblasts
Cardiac Myocytes
Orange CMRA
Green CMFDA
Merge
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Interactions Between Cardiac Fibroblasts and
Myocytes
Cardiac Fibroblasts Green
Cardiac Myocytes Orange
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USC INBRE PROGRAM
JEFFERY BISCHOFF Fibroblast-Myocyte-ECM
Interaction
Overall goal- to understand the mechanics of the
formation of ECM-fibroblast-myocyte contact
(papillary muscle model)
Progress- Abstracts at BMES, AHA grant in
preparation for January submission, NIH-R21
grant in preparation
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Diagram illustrating the stages in the process of
valvular morphogenesis. Dark blue is endocardium
and cushion mesenchyme Light blue is ECM Red is
myocardial tissue .
Adapted from Roger Markwald, Medical School of
South Carolina
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Cell stretching
Custom developed uniaxial stretching system. This
system can apply cyclic uniaxial deformation to
the cell-cell interface. The deformation is
applied to the silicone rubber sheet using a 1.8
degree stepper motor and a mechanical controller
(Newmark System Inc. Mission Viejo, CA) with a
displacement resolution of 0.02 micrometers. The
movement of the motor is programmed by OMS
Terminal (Oregon Micro Systems, Inc, Beaverton,
OR)
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USC INBRE PROGRAM
SUSAN LESSNER Angiogenesis and Capillary
Permeability in Atherosclerotic Lesions
Overall goal- understand the regulation of
capillary growth and permeability in
atherosclerotic lesion
Progress- Established model, making measurements,
AHA grant in preparation for January
submission
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Angiogenesis in Experimental Atherosclerosis
Fluorescence microangiography of mouse carotid
artery lesion
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USC INBRE PROGRAM
SARAH BAXTER ECM Receptor and ECM Matrix
Organization
Overall goal- to understand the dynamic between
ECM receptors, organization of the ECM, and
mechanical force.
Progress- NSF grant submitted, abstracts for
American Society for Cell Biology, NIH RO1
planned for June 1.
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(No Transcript)
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USC INBRE PROGRAM
WORKSHOP
APPLICATION OF IMAGING TO RESEARCH
LEADERS ROBERT PRICE (USC) AND JAY JEROME
(VANDERBILT)
TWO DAY, HANDS ON LECTURE AND DEMONSTRATION OF
CONFOCAL MICROSCOPY IMAGE ANALYSIS
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USC INBRE PROGRAM
STATUS
SYMPOSIUM FOR THIS SPRING IS IN DEVELOPMENT TO BE
HELD AT CLEMSON
TENTATIVE AREAS OF EMPHASIS INCLUDE VASCULAR
BIOLOGY ARTIFICIAL MATRICES MARKERS OF
DIFFERENTIATION
CHAIRS IN REGENERATIVE MEDICINE SEARCH
COMMITTEES FORMED, OFFERS BEING MADE
OUTSIDE REVIEW TEAM ALLEN SAMAREL LOYOLA
UNIVERSITY MIKE ZILE, MUSC JEFF
HOLMES, COLUMBIA