Biology%20of%20Influenza%20A

1
Will Avian Influenza become Human?

• Question How could H5N1 become dangerous to
  humans?
• Mutation of H5 to bind to human receptors?
• Re-assortment by genetic shift to H1N1?

Biology of Influenza A
H5N1 and H1N1 ClustalW separates man from
bird. http//workbench.sdsc.edu
http//www.vetscite.org/publish/articles/000041/im
g0002.jpg
From PDB Molecule of the Month
H (16 types)N (9types) designation H types that
infect humans 1, 2, 3 H types that infect birds
3, 4, 6 (freq) 5,7 less common Bird FluH5N1
http//www.ebi.ac.uk/interpro/potm/2006_4/Page1.ht
m
Ab covering HA
Genetic shift vs. drift
A/Thailand/1KAN-1A/2004H
CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/Vietnam/PEV16T/2005H5N1
CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVMWGIHHPNDA
A/chicken/Thailand/Kanchana
CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/chicken/Thailand/Nontabur
CPYQGKSSFFRNVVWLIKKNSTYPIIKRSYNNTNQEDLLVLWGIHHPNDA
A/quail/Thailand/Nakhon_Pat
CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/goldeneye_duck/Bavaria/19/
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/tufted_duck/Bavaria/9/2006
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/swan/Bavaria/16/2006H5N1
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/swan/Bavaria/6/2006H5N1
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/buzzard/Bavaria/5/2006H5N
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/tufted_duck/Bavaria/8/2006
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/swan/Bavaria/17/2006H5N1
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/swan/Bavaria/21/2006H5N1
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/teal/Egypt/14051-NAMRU3/2
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/goosander/Switzerland/V82/
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/chicken/Egypt/10845-NAMRU
CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA
A/goose/Guangzhou/471/2006
CPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDA
A/China/GD01/2006H5N1
CPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNNA
A/Owston's_civet/Vietnam/1/2
CPYQGNSSFFRNVVWLIKKNDAYPTIKRSYNNTNQEDLLVLWGIHHPNDE
A/Indonesia/CDC887/2006H5N
CPYLRSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNNE
A/Indonesia/CDC836T/2006H5
CPYLGSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNDA
A/teal/Egypt/9885-NAMRU3/20
CPYNGRSSFFRNVVWLIKKNNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

.. .
A/Thailand/1KAN-1A/2004H
AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSEVNGQSGRMEFFWTILK
A/Vietnam/PEV16T/2005H5N1
AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK
A/chicken/Thailand/Kanchana
AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK
A/chicken/Thailand/Nontabur
AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK
A/quail/Thailand/Nakhon_Pat
AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRPKVNGQSGRMEFFWTILK
A/goldeneye_duck/Bavaria/19/
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/tufted_duck/Bavaria/9/2006
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/swan/Bavaria/16/2006H5N1
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/swan/Bavaria/6/2006H5N1
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/buzzard/Bavaria/5/2006H5N
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/tufted_duck/Bavaria/8/2006
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/swan/Bavaria/17/2006H5N1
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/swan/Bavaria/21/2006H5N1
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/teal/Egypt/14051-NAMRU3/2
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/goosander/Switzerland/V82/
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/chicken/Egypt/10845-NAMRU
AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/goose/Guangzhou/471/2006
AEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILK
A/China/GD01/2006H5N1
AEQTKLYQNPTTYISVGTSTLNLRLVPKIATRSKVNGQSGRMDFFWTILK
A/Owston's_civet/Vietnam/1/2
AEQTRLYQNPTTYVSIGTSTLNQRLVPKIATRSKVNGQSGRIDFFWTILK
A/Indonesia/CDC887/2006H5N
AEQTRLYQNPTTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK
A/Indonesia/CDC836T/2006H5
AEQTRLYQNPTTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWAILK
A/teal/Egypt/9885-NAMRU3/20
AEQTKLYQNPTTYVSVGTSLLNQRSVPEIATRPKVNGQSGRMEFFWTILK

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