Research Genetics

1
Genomics Building Blocks

• Sequence
• Maps
• Markers

2
Genomic DNA Sequence

• Human
• Mouse
• And many others (completed or underway)
• C. elegans
• D. melanogaster
• S. cerevisiae http//genome-www.stanford.edu/Sacch
  aromyces/
• Arabidopsis
• Rice http//www.tigr.org/tdb/rice/
• various prokaryotes

3
http//www.ncbi.nlm.nih.gov/genome/guide/
Current estimate July 2000 Possibly sooner?
4
http//www.ncbi.nlm.nih.gov/genome/guide/
5
http//www.ncbi.nlm.nih.gov/genome/guide/
Use hot buttons to follow the area of interest
http//www.ncbi.nlm.nih.gov/LocusLink
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http//www.ncbi.nlm.nih.gov/genome/guide/
Each window can be drawn with a specific level
of detail
7
http//www.ncbi.nlm.nih.gov/LocusLink
Sequence can be obtained from this same window
8
http//www.ncbi.nlm.nih.gov/genome/seq/MmHome.html
9
http//bacpac.med.buffalo.edu/mouse/overview.html
10
http//www.ncbi.nlm.nih.gov/dbEST/index.html

• Human
• Mouse, Rat
• Dog, Cat, Rabbit
• Zebrafish, Halibut, Catfish, Shrimp, Trout,
  Salmon, Lumpfish, Carp
• Fruitfly, Horn Fly, Mosquito
• Pig, Cow, Goat, Sheep, Chicken, Turkey
• C. elegans, C, briggsae
• S. cervisiae, C. albicans
• And many, many others

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http//www.ncbi.nlm.nih.gov/UniGene/
Organisms
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http//www.ncbi.nlm.nih.gov/UniGene/
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http//www.ncbi.nlm.nih.gov/UniGene
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http//www.ncbi.nlm.nih.gov/genemap98/
15
http//www4.ncbi.nlm.nih.gov/htbin-post/Entrez/
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http//www.ncbi.nlm.nih.gov/Homology/
Homology mapping
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http//www.informatics.jax.org/menus/homology_menu
.shtml
cat cattle chimpanzee dog goat gorilla guinea
pig hamster(s) horse mouse lemur orangutan pig
platypus rabbit sheep tammar wallaby
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http//www.informatics.jax.org/searches/oxfordgrid
_form.shtml
mouse human cat cattle pig rat sheep
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http//www.ncbi.nlm.nih.gov/genome/rhmap
RH maps
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http//www.well.ox.ac.uk/rat_mapping_resources/
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http//ratmap.ims.u-tokyo.ac.jp/
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http//waldo.wi.mit.edu/rat/public/
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http//ares.ifrc.mcw.edu/maps-bin/rh_placement.cgi
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http//www-genome.wi.mit.edu/mouse_rh/index.html
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http//gdbwww.gdb.org/

• Markers

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http//ratest.eng.uiowa.edu/cgi-bin/map-info
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http//gdbwww.gdb.org/
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http//gdbwww.gdb.org
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http//www.cephb.fr/cgi-bin/wdb/ceph/systeme/query
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http//www.cephb.fr/cgi-bin/wdb/ceph/systeme/query
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http//rgd.mcw.edu/TOOLS/QUERY/genome_scanner.html
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http//carbon.wi.mit.edu8000/cgi-bin/mouse/index
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http//carbon.wi.mit.edu8000/cgi-bin/mouse/index
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http//www.informatics.jax.org/searches/polymorphi
sm_form.shtml
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http//www.resgen.com