Folic Acid

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Folic Acid

• I am not responsible for errors
• Nosaj

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• This is a deficiency of normal sized erythrocytes

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• Normocytic
• Deficiency of normal sized erythrocytes
• Iron Deficiency
• Hemorrhage
• Hemolysis
• Anemia of chronic disease (autoimmune disease,
  cancer etc.

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• This is a deficiency of hemoglobin leading to
  small sized erythrocytes.

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• Microcytic
• Causes include Iron deficiency

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• This is a condition where the erythrocytes are
  larger than normal.

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• Megaloblastic
• Causes
• Folic acid
• Cobalamin (cyanocobalamin)

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• This is a decreased ability of the bone marrow to
  make new erythrocytes.

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• Aplastic Anemia

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• Defective Hemoglobins

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• Sickling Disease (Sickle Cell Anemia)
• Thalessemias

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• Folic acid was discovered by who?

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• Professor Snell (U of Texas)

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• What is the recommened dose of Folic acid for
  women contemplating pregnancy?

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• 0.4mg (400 µg) to 1 mg (1,000 µg)
• Why are women recommended to take this vitamin?

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• Women are recommened to take this vitamin to
  prevent neural tube defects (NTDs) such as spina
  bifida and anencephaly.

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• The commercial form of folic acid is comprised of
  what?

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• Pteridine ring
• p-aminobenzoate
• glutamate

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• Dietary polyglutamates are cleaved to the
  monoglutamate vitamin by a

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• ?-L-glutamylcarboxy peptidase commonly called
• conjugase

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• Folic acid and tetrahydrofolate are absorbed as
  the _________ from

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• Monoglutamate

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• What does methotrexate do?

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• Methotrexate inhibits the conversion of Folic
  acid to tetrahydrofolate (THF, FH4)

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• How many forms of folic acid are cofactors?

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• Four forms.

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• 5,10-methylene THF (N5,N10-methylene THF)
• What does this form of the cofactor do?

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• N5,N10-methylene THF
• Methylation of dUMP forming dTMP
• Synthesis of serine from glycine.
• I bet the some guy in a lab named this dump after
  taking a shit.
• Man today I took like 5 to 10 dumps and now I
  have a lot sering and no gliding.

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• What does the 10-formyl THF form of folic acid do?

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• 10-formyl THF
• Conversion aminoimidazole carboxamide fibotide
  (AICAR) to Formamidoimidazole carbxamide ribotide
  (FAICAR) in purine biosynthesis.

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• 5,10 methenyl THF

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• Synthesis of formylglycine ribotide (FGAR) from
  glycine amide ribotide (GAR) in purine
  biosynthesis.

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• 5 methyl THF (N5-methyl THF)

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• Methylation of homocysteine forming methionine
• Important
• This is the one cofactor form which is not
  interchangeable with any of the other cofactor
  structures.
• It is the predominant

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• This cofactor of folic acid undergoes methylation
  of homocysteine forming methionine.

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• 5 methyl THF (N5-methyl THF)
• Methylation of homocysteine forming methionine.
• This is the one cofactor form which is not
  interchangeable with any of the other cofactor
  structures.

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• This is the administered form of folic acid
  following methotrexate therapy to return
  tetrahydrofolate activity to normal levels in
  benign tissues.

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• 5-Formyl THF (Folinic acid, citrovorum factor)

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