THE FLY THAT WOULD BE KING - PowerPoint PPT Presentation

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THE FLY THAT WOULD BE KING

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Trypanosoma vivax Old and New World of large mammals ... Thompson's gazelle. Warthog. Impala. Oryx. Domesticated Reservoir Hosts. N'dama. Zebu. Warthogs ... – PowerPoint PPT presentation

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Title: THE FLY THAT WOULD BE KING


1
THE FLY THAT WOULD BE KING
Glossina
2
African Sleeping Sickness
300-500,000
3
African trypanosomiasisTrypomastigote morphology
4
Salivarian trypanosome groups
Trypanosoma vivax Old and New World of large
mammals Mechanical transmission using many
vectors Trypanosoma congolense Old World of
large mammals Mouthpart development in
Glossina Trypanosoma brucei/evansi brucei
group includes T. brucei brucei nagana in
cattle T. brucei gambiense
chronic or West African sleeping
sickness T. brucei rhodesiense
acute or East African sleeping
sickness All have full development in
Glossina evansi group includes T. evansi
mechanical transmission in many vectors
including vampire bats T.
equinum mechanically transmitted by
horse flies T. equiperdum
sexually transmitted
5
Trypanosoma Life Cycle
6
Trypanosome Antigenic Variation
7
Tsetse Fly and Human Disease Distribution
8
Tsetse Fly and Cattle Distribution
9
African Ecology and Vector Distribution
Glossina palpalis group
Glossina palpalis group
Glossina morsitans group
10
Glossina Life Cycle
8 9 days
6(male) 14(female) weeks
4 5 weeks
11
Glossina Life Cycle (cont.)
12
Glossina - Life Cycle (cont.)
13
Natural Reservoir Hosts
Thompsons gazelle
Impala
Oryx
Warthog
14
Domesticated Reservoir Hosts
Ndama
Zebu
Warthogs
15
Trypanotolerant Cattle Populations
16
Trypanosomiasis Risk - Humans
17
Human Population Density - Africa
18
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20
Tsetse surveilance
Uganda
21
Tsetse Control
22
African trypanosomiasisDiagnosis
23
African trypanosomiasisTreatment
Suramin - Pentamidine (early)
Melarsoprol (late)
DFMO
Aventis Pharm WHO
24
Africa Deforestation
25
Africa Grassland burning
Tanzania
Zambezi River
26
Displaced Populations
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