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African trypanosomiasis Trypanosoma brucei

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Mechanical transmission using many vectors. Trypanosoma ... gazelle. impala. oryx. African trypanosomiasis - Distribution. West African = Trypanosoma gambiense ... – PowerPoint PPT presentation

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Title: African trypanosomiasis Trypanosoma brucei


1
African trypanosomiasisTrypanosoma brucei
2
Salivarian trypanosome groups
Trypanosoma vivax Old and New World of large
mammals Mechanical transmission using many
vectors Trypanosoma congolense Old World of
large mammals Mouthpart development in
Glossina Trypanosoma brucei/evansi brucei
group includes T. brucei brucei nagana in
cattle T. brucei gambiense
chronic or West African sleeping
sickness T. brucei rhodesiense
acute or East African sleeping
sickness All have full development in
Glossina evansi group includes T. evansi
mechanical transmission in many vectors
including vampire bats T.
equinum mechanically transmitted by
horse flies T. equiperdum
sexually transmitted
3
African trypanosomiasisTrypomastigote morphology
4
African trypanosomiasisKinetoplast DNA changes
5
African trypanosomiasisReservoir hosts
gazelle
gerenuk
impala
oryx
6
African trypanosomiasis - Distribution
West African Trypanosoma gambiense East African
Trypanosoma rhodesiense
7
African trypanosomiasisResistant and susceptible
cattle
Ndama
Zebu
8
African trypanosomiasisThe tsetse fly
9
African trypanosomiasisLife cycle
10
African trypanosomiasisAntigenic variation
11
Immune response overview
12
African trypanosomiasisDisease
13
African trypanosomiasisDiagnosis
14
African trypanosomiasisTreatment
Suramin - Pentamidine (early)
Melarsoprol (late)
DFMO
Aventis Pharm WHO
15
African trypanosomiasisPrevention and Control
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