Title: African trypanosomiasis Trypanosoma brucei
1African trypanosomiasisTrypanosoma brucei
2Salivarian trypanosome groups
Trypanosoma vivax Old and New World of large
mammals Mechanical transmission using many
vectors Trypanosoma congolense Old World of
large mammals Mouthpart development in
Glossina Trypanosoma brucei/evansi brucei
group includes T. brucei brucei nagana in
cattle T. brucei gambiense
chronic or West African sleeping
sickness T. brucei rhodesiense
acute or East African sleeping
sickness All have full development in
Glossina evansi group includes T. evansi
mechanical transmission in many vectors
including vampire bats T.
equinum mechanically transmitted by
horse flies T. equiperdum
sexually transmitted
3African trypanosomiasisTrypomastigote morphology
4African trypanosomiasisKinetoplast DNA changes
5African trypanosomiasisReservoir hosts
gazelle
gerenuk
impala
oryx
6African trypanosomiasis - Distribution
West African Trypanosoma gambiense East African
Trypanosoma rhodesiense
7African trypanosomiasisResistant and susceptible
cattle
Ndama
Zebu
8African trypanosomiasisThe tsetse fly
9African trypanosomiasisLife cycle
10African trypanosomiasisAntigenic variation
11Immune response overview
12African trypanosomiasisDisease
13African trypanosomiasisDiagnosis
14African trypanosomiasisTreatment
Suramin - Pentamidine (early)
Melarsoprol (late)
DFMO
Aventis Pharm WHO
15African trypanosomiasisPrevention and Control