Department of Health and Human Services

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Department of Health and Human Services National
Institutes of Health National Center for
Research Resources Division of Research
Infrastructure (DRI) Overview of the National
Center for Research Resources, NIH Sidney A.
McNairy, Jr., Ph.D., D.Sc. Director, DRI May 5,
2005
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Mission The National Institutes of Health
...to acquire new knowledge that will improve
the health of all citizens
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National Center for Research
Resources Mission ...to strengthen and
enhance the research environments of entities
engaged in health-related research by developing
and supporting essential research resources.
PHS Act, Title III, Part E, Section 479
Dr. Alving, Acting Director, NCRR


Research
Biomedical
Clinical
Comparative
Infrastructure
Technology
Research
Medicine
Dr. Michael
Dr. Anthony
Dr. Franzskia
Dr. Sidney
Marron
Hayward
Greider
McNairy
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National Center for Research Resources
FY 2004 Appropriations (in thousands of
dollars)
NCRR Total 1,179,058,000
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National Center for Research Resources
FY 2005 Appropriations
(Dollars in thousands)
Biotechnology
(318,531)
NCRR Total 1,115,090,000
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Division of Research Infrastructure
GOAL TO DEVELOP THE NATIONS CAPACITY FOR
BIOMEDICAL RESEARCH BY PROVIDING SUPPORT FOR THE
DEVELOPMENT OF RESEARCH INFRASTRUCTURE
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Division of Clinical Research Resources

• Objective
• provide funding to biomedical research
  institutions to establish and maintain
  specialized clinical research facilities and
  clinical-grade biomaterials that enable clinical
  and patient-oriented research.

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Division of Clinical Research Resources
Activities

• General Clinical Research Centers-78
• National Gene Vector Laboratories
• Clinical Research Resources
• Islet Cell Resource Centers
• Human Tissues and Organs Resource
• Clinical Research Career Development
• Science Education Partnership Award

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Division of Comparative Medicine

• Objective meet the needs of biomedical
  researchers for high-quality, disease-free
  animals and specialized animal research
  facilities

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Division of Comparative Medicine
Activities

• Laboratory Animal Sciences
• Mutant Mouse Regional Resource Centers
• National Primate Research Centers
• Biological Repositories
• Biological Models and Materials Research
• AIDS Animal Models
• NIH Chimpanzee Management Program
• Research Training and Career Development
• Investigator-Initiated Research Grants

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Division of Biomedical Research Technology

• Objective develop and adapt existing
  instrumentation and technology for biomedical
  research

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Division of Biomedical Research Technology
Activities

• Shared Instrumentation Grants
• High-End Instrumentation Grants
• Biomedical Technology Resource Centers for
  Research and Development (RD) of New
  Technologies
• Biomedical Technology Resource Centers
• Biomedical Informatics Research Network (BIRN)
• Investigator-Initiated Research Grants for
  Technology RD
• Investigator-Initiated Research Grants

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Division of Research Infrastructure

• Objective develop research infrastructure for
  biomedical research

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Division of Research Infrastructure
Activities

• Institutional Development Award (IDeA) Program
• Facilities Improvement Programs
• Research Centers in Minority Institutions (RCMI)
  Program

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Division of Research Infrastructure
FY 2004 Appropriations (in thousands of dollars)
DRI Total 399,209,000
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Division of Research Infrastructure Animal
Facilities Improvement Program

• Funds to upgrade animal research facilities
• Comply with Federal laws, regulations, and
  policies
• Develop centralized programs of animal care

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Research Facilities Improvement Program Trends
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Animal Facilities Improvement Program Trends
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Division of Research Infrastructure Research
Centers in Minority Institutions Budget History
(in millions)
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Division of Research Infrastructure Research
Centers in Minority Institutions Budget
History for all programs (in millions)

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Characteristics of Future Research

• Biocomplexity
• Multidisciplinary teams - medicine (basic and
  clinical), bioengineers, bioinformaticists,
  mathematicians, physicists, computer specialists
• Integrative or systems approach more dependent on
  technologies
• Information management at core of biology for the
  21st century

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NCRR Priority-Setting Criteria for Developing New
Research Tools, Technologies, and Resources At
cutting edge of innovation in research tools and
technologies includes high-risk and long-term
research that may have high societal
payoff Cost-saving, efficient, shared, and
accessible Responsive to unexpected
opportunities and ever-changing research resource
needs Scarce and expensive with limited
access Multidisciplinary and collaborative,
serving to integrate research for complex
biomedical problems
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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Building Blocks, Pathways and Networks
• National Technology Centers for Networks and
  Pathways
• Metabolomics Technology Development
• Standards for Proteonomics and Metabolomics/Assess
  ment of Critical Reagents for Proteonomics

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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Building Blocks, Pathways, and Networks
  Implementation Group
• National Technology Centers for Networks and
  Pathways.
• Metabolomics Technology Development.
• Standards for Proteomics and Metabolomics/Assessme
  nt of Critical Reagents for Proteomics.
• Molecular Libraries and Imaging Implementation
  Group
• Creation of NIH Bioactive Small Molecule Library
  and Screening Centers.

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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Molecular Libraries and Imaging
• Cheminformatics
• Bioinformatics and Computational Biology
• Development of High Specificity/High Sensitivity
  Probes to Improve DetectionProduction Faccilities
• Nanomedicine

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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Re-engineer Clinical Research
• Technology driven
• Emphasize on translation research

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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Molecular Libraries and Imaging
• Cheminformatics comprehensive database of
  chemical structures and their biological
  properties now being developed by the National
  for Biotechnology Information at NIH PubChem
  will house compound information as well as
  molecular probe data

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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Molecular Libraries and Imaging
• Bioinformatics and Computational Biology create
  a national software engineering system in which
  biologists, chemist, physicists and computer
  scientists can tap into a supercomputering
  network to share and analyze data

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NIH Roadmap - Theme New pathways to Discovery
http//nihroadmaphttp//

• Molecular Libraries and Imaging
• Nanomedicine quantitative measurements of
  biological processes at the nanoscale level and
  development of new tools to intervene at the
  nanoscale or molecular level can lead to
  implantable devices that can scan for infectious
  agents or metabolic imbalances

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