Build up of Amyloid in Alzheimers Disease arrow

1
Build up of Amyloid in Alzheimers
Disease (arrow)
2
Removal of brain amyloid in an AD patient
following active immunization (top) Persistence
of brain amyloid in a non- immunized patient
(bottom)
Amyloid (red) in non-immunized mouse (top) is
removed in mice after immunization (bottom)
3
Medications may promote removal of amyloid by
interfering with clumping of amyloid fibrils
4
New medications may prevent deposits of amyloid
by modulating specific enzymes
alpha-secretase
Abeta-42
Abeta-40
Abeta-42
Selkoe DJ et al. JAMA. 20002831615-1617.