High InsulinSensitivity In LongLived Mice

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High Insulin-Sensitivity In Long-Lived
Mice Terry P. Combs, PhD Department of
Nutrition Schools of Public Health and
Medicine University of North Carolina at Chapel
Hill 3/20/2006
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100
80
calorie-restricted rats
control rats
60
Rat Survival
40
20
0
48
0
6
12
18
24
30
36
42
Age (months)
3
Adrenals
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overlapping features of long-lived mouse-models
calorie- restricted
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all long-lived mouse-modelsare more
insulin-sensitivethan control mice
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Our main goal determine whether high
insulin-sensitivity is linked to longevity
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high insulin-sensitivity in long-lived
miceinsulin Low circulating glucose Low
fasting glucose-turnover Low
endogenous glucose production Low
gluconeogenesis Lowglycogenolysis Low
free fatty acid-turnover
Highliver/muscle lipid deposits Low liver
ACC Low
adiponectin High
hemoglobin A1c No Difference
(ND)ROS-derived DNA-adducts low or ND
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high insulin-sensitivity in long-lived
miceinsulin Low circulating glucose Low
fasting glucose-turnover Low
endogenous glucose production Low
gluconeogenesis Lowglycogenolysis Low
free fatty acid-turnover
Highliver/muscle lipid deposits Low liver
ACC Low
adiponectin High
hemoglobin A1c No Difference
(ND)ROS-derived DNA-adducts low or ND