NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

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NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
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NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
SMALL BUSINESS RESEARCH OPPORTUNITIES PHYLLIS
MITCHELL NATIONAL HEART, LUNG AND BLOOD DIVISION
BLOOD DISEASES AND RESOURCES [phone] FAX
[phone] MITCHELP_at_NHLBI.NIH.GOV
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NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• The NHLBI SBIR/STTR program fosters research on
• Pharmaceuticals
• Medical Devices and Implants
• Biologics
• Informatics
• Biotechnologies
• for the causes, prevention, diagnosis and
  treatment of heart, blood vessel, lung, blood
  diseases and sleep disorders.

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NHLBI Extramural Divisions
Division of Heart and Vascular Diseases
Div. of Epidemiology and Clinical Applications
Division of Lung Diseases Division of Blood
Diseases and Resources National Center on
Sleep Disorders Research
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NHLBI SBIR Home Pagehttp//www.nhlbi.nih.gov/fun
ding/sbir/index.htm NHLBI Mission
Statement Staff Contacts NIH Omnibus
Notices NHLBI Topics Model SBIR
Application
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Examples of Awarded Projects

• Improved Hollow Fibers for Intravenous Blood
  Oxygenators
• Gene Delivery Systems for Broncho-Alveolar
  Diseases
• Novel Ex Vivo Expansion of Cord Blood Progenitors
• Automated Quantitation of 3D Echocardiograms
• Coated Electrosurgical Blade

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Examples of Awarded Projects

• Automated Process for a Tissue Engineered Blood
• Antisense Therapeutics for Treatment of Cyctic
  Fibrosis
• Improved Vectors for Therapeutic Protein
  Production
• Intraluminal Robot Assisted Mitral Valve Repair
• An Expert System to Improve Medication Adherence

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VISIT THE NATIONAL INSTITUTES OF HEALTH SMALL
BUSINESS FUNDING OPPORTUNITIES WEBSITE
http//grants.nih.gov/grants/funding/sbir.htm

• SPECIAL ANNOUNCEMENTS FOR
• SMALL BUSINESS RESEARCH PROJECTS
• http//grants.nih.gov/grants/funding/sbir_announce
  ments.htm

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TECHNOLOGIES TO IMPROVE THE UTILITY OF ANIMAL
MODELS This Program Announcement encourages
the small business community to develop
technologies, reagents, and equipment to improve
the utility of animal models for biomedical
research http//grants.nih.gov/grants/guide/pa-
99-048.html
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Examples of Awarded Projects

• Rat Models to Screen Compounds Inducing Slow Wave
  Sleep
• Development of a Transgenic Rat Atherosclerosis
  Model
• Tools and Techniques to Measure Blood Flow and
  Pressure in Mice
• Development of Microimaging Techniques for use in
  Small Animals
• Opitimization of Rodent Models of Transplant CAD

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STUDY AND CONTROL OF MICROBIAL BIOFILMS
This Program Announcement is designed to support
the development of technologies and strategies
for the prevention and treatment of microbial
biofilm-associated diseases.
http//grants.nih.gov/grants/guide/pa-99-084.html
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Examples of Research Topics

• Development of Improved Imaging of Biofilms in
  situ
• Development of systems for the Study of
  Biofilm-Specific Gene Expression Exchange of
  Genetic Material within Biofilms
• Development of Mathematical Models Computer
  Simulations of Biofilms
• Techniques or Assays for Studies of Host Immune
  Responses

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Examples of Research Topics

• Technologies to Enhance the Sensitivity of
  Biofilms to Antimicrobial Agents
• Technologies for Studies of Pathogenic Mechanisms
  of Microbes Growing in Biofilms
• Technologies and Materials Relevant to the
  Interaction of Biofilms with Host Tissues and
  Artificial Implants

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PROTEIN STRUCTURE INITIATIVE (STRUCTURAL
GENOMICS) The purpose of this Program
Announcement is to encourage research on the
development of methodology and technology
underpinning the emerging field of structural
genomics, whose goal is the understanding of
protein structural families, structural folds,
and the relation of structure and function.
http//grants.nih.gov/grants/guide/pa-files/pa-99-
117.html
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Examples of Research Topics

• Development of Methods
• for selecting representative protein families
  based on enhancement of structure space coverage
  or functional significance.
• for high throughput production of target proteins
  suitable for structure determination
• for high throughput data collection

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Examples of Research Topics

• Development of Methods
• for automated determination, validation and
  analysis of 3D structures.
• for homology-based modeling, related methods, and
  validation of modeled structures
• for informatics systems to optimize support the
  process of structure determination

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BIOENGINEERING NANOTECHNOLOGY INITIATIVE
This Program Announcement, issued as an
initiative of the trans-NIH Bioengineering
Consortium (BECON), invites grant applications
for Small Business projects on nanotechnologies
useful to biomedicine. http//grants.nih.gov/gra
nts/guide/pa-files/pa-00-018.html
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Examples of Research Topics

• Nanoplumbing components.Valves microfluidic
  channels, motorsthat can be operated from a
  distance.
• Logic Circuits.based on quantum dots which carry
  out computing functions without current flow
• Fluorescent probes at nanometer scale for
  monitoring biochemical processes on the surface
  and inside the cell

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Examples of Research Topics

• Nanofabricated barriers to control rejection of
  implantable materials
• Nanoparticles and nanospheres that enable
  controlled release of therapeutic agents,
  antibodies, genes and vaccines
• Biotemplates and sensor technologies for
  detection and analysis of DNA and RNA targets in
  body fluid samples
• Smart nanostructured biocompatible materials

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http//grants.nih.gov/grants/guide/pa-files/pa-00-
018.html BIOENGINEERING NANOTECHNOLOGY
INITIATIVE PA NUMBER PA-00-018 Release Date
December 2, 1999   National Cancer
Institute National Center for Research
Resources National Eye Institute National Human
Genome Research Institute National Heart, Lung,
and Blood Institute National Institute on
Aging National Institute on Alcohol Abuse and
Alcoholism National Institute of Allergy and
Infectious Diseases National Institute of
Arthritis and Musculoskeletal and Skin
Diseases National Institute of Child Health and
Human Development National Institute on Drug
Abuse National Institute on Deafness and Other
Communication Disorders National Institute of
Dental and Craniofacial Research National
Institute of Diabetes and Digestive and Kidney
Diseases National Institute of Environmental
Health Sciences National Institute of General
Medical Sciences National Institute of Mental
Health National Institute of Neurological
Disorders and Stroke National Library of
Medicine  APPLICATION RECEIPT DATES April 1,
August 1, and December 1 in the years 2000, 2001,
and 2002.  
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NHLBI Contacts

• Heart and Vascular Disease
• Dr. John T. Watson watsonj_at_nhlbi.nih.gov
• [phone] Fax [phone]
• Dr. Rosalie Dunn dunnr_at_nhlbi.nih.gov
• [phone] Fax [phone]
• Lung Diseases
• Dr. Robert Musson mussonr_at_nhlbi.nih.gov
• [phone] Fax [phone]
• Ms. Ann Rothgeb rothgeba_at_nhlbi.nih.gov
• [phone] Fax [phone]

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NHLBI Contacts

• Blood Diseases and Resources
• Ms. Susan Pucie Pucies_at_nhlbi.nih.gov
• [phone] Fax [phone]
• Epidemiology and Clinical Applications
• Dr. Thomas Blaszkowski blaszkot_at_nhlbi.nih.gov
• [phone] Fax [phone]
• Administrative and Business Management
• Mr. Ed Donohue donohuee_at_nhlbi.nih.gov
• [phone] Fax [phone]

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REMEMBER

• NHLBI Staff are enthusiastic about hearing your
  ideas and providing advice
• In addition to Your good ideas Check the
  Websites for Research Topics
• Write that Quality Scientific Grant
• NHLBI wants to do Business with YOU