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Corporate EHS Strategic Perspective

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Pfizer is the largest pharmaceutical company in the world. Human health. Consumer health care ... Pharmaceutical companies doing green chemistry ... – PowerPoint PPT presentation

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Title: Corporate EHS Strategic Perspective


1
Corporate EHS Strategic Perspective
  • Michael Rottas
  • Associate Director, Environmental Health Safety
  • Pfizer Global RD Groton/New London Laboratories

2
  • Pfizer is the largest pharmaceutical company in
    the world.
  • Human health
  • Consumer health care
  • Animal health
  • 120,000 employees worldwide
  • Operations in 150 countries
  • Largest privately funded research organization in
    the world.
  • Now 8 billion/year
  • Groton Labs 1.5 billion/year

3
  • Global Environmental Management Initiative (GEMI)
    member
  • UN Global Compact member
  • EPA Climate Leaders participant
  • Public Environmental Goals
  • Reduce CO2 emissions by 35 by 2007 (2000 as
    baseline)
  • 35 of global electricity needs by 2010 from
    clean sources
  • Phase out of Class I ODCs by 12/31/2005

4
Where we were
  • EHS professionals, in Corporate setting, were
    necessary overhead due to compliance requirements
  • Outsiders from manufacturing and operating units
  • Us vs. them
  • Niche role
  • Reactive
  • After the fact
  • End-of-line control

5
Where we are
  • EHS professionals are a respected participant in
    the business process
  • We are at the table
  • Resource for business risk minimization and
    continuity planning (post Y2K, post 9/11/2001)
  • Skills transferable, financially savvy
  • Proactive and preventative
  • Third party EMS registrations

6
Where we are going
  • Holistic approach to sustainable practices
  • Integrated EHS management systems
  • No longer separate, but integrated into core
    business functions
  • Technical professionals with sophisticated
    business skills (MBAs routine)
  • Everyone is involved, cultural approach

7
Industrial Evolution
  • Sustainability becoming more commonplace within
    the core business of leading businesses
  • Hybrid cars becoming mainstream
  • Petrochemical companies working on alternative
    fuels
  • Carpet companies making recyclable carpets
  • Pharmaceutical companies doing green chemistry
  • Investment firms recognize value in sustainable
    practices

8
What is green chemistry?
the utilization of a set of principles that
reduces or eliminates the use or generation of
hazardous substances in the design, manufacture
and application of chemical products.
Source Paul T. Anastas and John C. Warner,
Green Chemistry Theory and Practice (New York,
NY Oxford University Press Inc., 1998). ISBN 0
19 850698 8
9
12 Principles of Green Chemistry
  • It is better to prevent waste than to treat or
    clean up waste after it has formed.
  • Synthetic methods should be designed to maximize
    the incorporation of all materials used in the
    process into the final product.
  • Wherever practicable, synthetic methodologies
    should be designed to use and generate substances
    that possess little or no toxicity to human
    health and the environment.
  • Chemical products should be designed to preserve
    efficacy of function while reducing toxicity.
  • The use of auxiliary substances (e.g. solvents,
    separation agents, etc.) should be made
    unnecessary wherever possible and innocuous when
    used.
  • Energy requirements should be recognized for
    their environmental and economic impacts and
    should be minimized. Synthetic methods should be
    conducted at ambient temperature and pressure.

10
12 Principles of Green Chemistry
  • A raw material or feedstock should be renewable
    rather than depleting wherever technically and
    economically practicable.
  • Unnecessary derivatization (blocking group,
    protection/deprotection, temporary modification
    of physical/chemical processes) should be avoided
    wherever possible.
  • Catalytic reagents (as selective as possible) are
    superior to stoichiometric reagents.
  • Chemical products should be designed so that at
    the end of their function they do not persist in
    the environment and break down into innocuous
    degradation products.
  • Analytical methodologies need to be further
    developed to allow for real-time, in-process
    monitoring and control prior to the formation of
    hazardous substances.
  • Substances and the form of a substance used in a
    chemical process should be chosen so as to
    minimize the potential for chemical accidents,
    including releases, explosions and fires.

11
Raw Materials
Energy
Natural Resources
Product
NDA
PGM
Intellectual Property
Raw Materials
Waste
Energy
Global RD
Clinical Supply
Natural Resources
Air Emissions
Solid/Hazardous Wastes
Wastewater
12
Raw Materials
Energy
Natural Resources
Product
NDA
PGM
Intellectual Property
Raw Materials
Waste
Energy
Global RD
Clinical Supply
Natural Resources
Air Emissions
Control at the source, treat on or
off-site, recycle where possible. Reduce, reuse,
recycle.
Solid/Hazardous Wastes
Wastewater
Waste Minimization Pollution Prevention
13
Raw Materials
Green Chemistry
Energy
Natural Resources
Product
NDA
PGM
Intellectual Property
Raw Materials
Waste
Energy
Global RD
Clinical Supply
Natural Resources
Air Emissions
Solid/Hazardous Wastes
Wastewater
Waste Minimization Pollution Prevention
14
Sertraline (Zoloft)
  • Solvent use reduced from 60,000 to 6,000 gallons
    per ton of sertraline
  • Eliminated the use of 440 metric tons of titanium
    dioxide per year
  • Eliminating the use 150 metric tons of 35
    hydrochloric acid per year
  • Eliminating the use of 100 metric tons of 50
    sodium hydroxide per year
  • Increasing the efficiency of raw material, water
    and energy use
  • And, doubled the product yield.

15
Sertraline Process Solvent Waste/Kg
16
EPAs Presidential Green Chemistry Challenge
Award - 2002
17
How the amount of waste produced in the
manufacture of sildenafil (L of waste/kg of
product) has decreased over the past 13 years.
1816 L/kg
139 L/kg
31 L/kg
10 L/kg
Medicinal
Optimized
Commercial Route
Commercial Route
Chemistry
Med. Chemistry
(1997)
following solvent
1990
1994
recovery
18
Who does green chemistry?
  • Chemists
  • EHS folks may assist with making the business
    case and providing inspiration/recognition, but
    ultimately its the chemists who do this.
  • Example of integration

19
Why Green Chemistry?
  • Meets the challenge of the triple bottom line
  • Economic
  • Social
  • Environmental

20
Green Chemistry TBL
  • Economic Aspect
  • Lower cost of raw materials
  • Lower costs for environmental permitting and
    regulatory requirements
  • Lower costs on engineering controls for employee
    safety
  • Risk of loss due to accidents, on a macro
    perspective, decreases
  • Lower costs for environmental emissions control
    and treatment
  • Lower costs associated with inventory control
  • Competitive advantage

21
Green Chemistry TBL
  • Social Aspect
  • Fence line issues (odors, unplanned releases)
  • Resource sustainability for future generations
  • Public outreach/education programs
  • Pfizer reputation they expect us to do this

22
Green Chemistry TBL
  • Environmental Aspect
  • More efficient use of non-renewable natural
    resources
  • Less impact on the environment due to permitted
    wastewater discharges, air emissions, and
    hazardous waste treatment
  • Less risk of incidents and unplanned releases
  • Smaller environmental footprint

23
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