Healthcare Convergence: Delivering Personalized Healthcare

1
Healthcare Convergence Delivering Personalized
Healthcare

• April 4, 2005
• Peter Loescher
• President and CEO
• GE Healthcare Bio-Sciences

2
Challenge Facing Healthcare Today

• Increasing imbalance between infinite demand and
  finite resources
• Fundamental changes in diagnostics are key to
  more rational care
• Evolving medical practice Choosing rational vs.
  rationed care

3
Key Trends Shaping Healthcare Future
Toward Patients

• Increased Patient Responsibility Power
• Community (Not Hospital) Based Care Setting

1

• From Post-Symptomatic Diagnosis to
  Pre-Symptomatic Screening and Segmentation
• Personal Risk Profiles Targeted / Specialized
  Therapies

Prediction/ Segmentation
2
Clinical Convergence

• Diagnostic Tests (In Vivo In Vitro)
  Complementary Competitive
• Diagnostics and Therapies Linked
• Transfer Between Life Sciences Research Clinic

3
Productivity Driven
4

• Payors Demand Rigorous Cost/Benefit Analysis on
  Diagnostic and Therapeutic Choices

Information Driven
5

• Integrated, Accessible, Personalized Actionable
  Patient Information

4
Personalized Healthcare Opportunity
4T

• Aging Populations Entering Peak Earning Years
• New Demand from Emerging Opportunities in
  Genomics and Proteomics
• Consistent Rebounds from Short-Lived Government /
  Payer Shocks
• Technology Critical to Improvements in Efficiency
  and Care Quality

Global healthcare spend
5
Innovation Driving the Opportunity

• Technological Enablers
• Computing
• Telecommunications
• Molecular understanding of disease
• Electrical engineering

• Social drivers
• Patients have on-line access to information
• More proactive in defining care and treatment
  plans
• View healthcare as a "preventive" process
• Use information to influence lifestyle

6
Time for a Fundamental Change
Heart Disease
Cancer
Brain Disorders
50 die after 1st heart attack
One person in three will have cancer
20 aged 75-84 suffer from Alzheimers disease
7
Evolving Medical Practice 21st Century
Personalized Healthcare
Current Model
Illness
Symptom-based Diagnosis
Treatment
Recover or revisit
Costly and ineffective Most drugs only work in
33 of patients Rx side effects are a leading
cause of death in the U.S.
8
Evolving Medical Practice 21st Century
Personalized Healthcare
Future Model
Current Model
Illness
Genetic Predisposition
Stratified Population
Symptom-based Diagnosis
Monitoring and Prevention
Treatment
Recover or revisit
Diagnose
Costly and ineffective Most drugs only work in
33 of patients Rx side effects are a leading
cause of death in the U.S.
Treatment Selection
Treatment
Treatment Monitoring
Better Patient Outcomes Safer treatments
Cost-effective healthcare
9
The Genomic Revolution Enabling 21st Century
Healthcare
Columbus 1492
Gene Sequence 2001
10
Personalized Healthcare From "Late Disease" to
"Early Health"

• Improvement of clinical outcomes driven by
  molecular understanding of disease
• Reduction of damaging side-effects and treatment
  costs through tailored treatment
• Efficient patient management made possible by
  electronic medical records

2004
Diagnosis
Therapy
2010
Predisposition
Individualised therapy
Therapeutic monitoring
Predict
Diagnose
Inform
Treat
11
GE Healthcare Coming Together
Technologies
Bio-Sciences

• Only GE Healthcare
• Combines
• Information Technology
• Imaging And Intervention
• Molecular Diagnostics
• Pharmaceutical Solutions

12
GE Healthcare Today
Medical Diagnostics
Complementary Platforms Accelerate Molecular
Imaging, coupled with systems for Drug Discovery

• New Market in PET
• Targeted Agents

Information Technology
Cellular
Services
Life Sciences

• Partnership
• Whole Hospital
• Performance ROI

• Physician Workflow
• Paperless, Filmless, Wireless

• Rational Drug Development
• In-Vivo Diagnostics

Evolution
Organ
Diagnostic Imaging
Clinical IT Systems
Clinical Application
Hospital Productivity

• Technology Innovation
• Clinical Productivity
• Globalization

Molecular Imaging
Evolution
Evolution
Evolution
Maintenance
PACS
Molecular Discovery
Evolution
Anatomical Imaging
13
Personalized Healthcare Benefits
Today
Tomorrow

• Disease Focus ?? Driving Better Outcomes
• Localization Demands ?? Enabling Responsive
  Globalization
• Enabling Technologies ?? Advancing Digitization
• Payor Influence ?? Driving New Models of
  Collaboration
• GE Healthcare Focus Areas

Radiology Reading
Cardiology
14
Cardiovascular Disease Today

• Main cause of death in the European population
• 4.4 million deaths in Europe
• 1/3rd of years of life lost from early death due
  to CVD
• Cardiovascular disease represents approximately
  169 billion a year

Source European Cardiovascular disease statistics
15
Cardiology Solutions Today and Tomorrow GE
Healthcare

• GE solution Lightspeed VCT for CT Angiography
• Detects 1 Killer Heart Disease
• Non-invasive 5 sec exam early detection
• Avoid unnecessary invasive procedures
• Reduce patient cost

16
Breast Cancer Today
350,000 women in Europe diagnosedwith breast
cancer every year

• Every 2.5 minutes a woman in the EU is diagnosed
  with breast cancer
• Every 6.5 minutes a woman in the EU dies of
  breast cancer
• The incidence rate in Europe is increasing each
  year
• Breast cancer is the most common cause of death
  from cancer in women

Breast cancer is the most common cause of death
from cancer in women
Early detection has caused mortality rates to
fall by 30 to 45
Source Breast cancer in the EU today
17
Breast Cancer Tomorrow GE to Address Overall
Disease Management
Result better, more cost-effective tailored
treatments and outcomes

• Diagnosis
• Biopsy
• Prognosis/Assessment
• General Staging
• Surgical Staging

• Surgery Guidance
• Therapy Selection
• Therapy Planning

• Therapy
• Monitoring Long-Term
• Follow-Up Diagnosis of Recurrence

• Screening

Predict
Diagnose
Inform
Treat
ProteomicsGenetics
Optical Biopsy
Gene Chips
Optical Functional Marker
Mammography In-Vitro Test
CT /MRI Radiation Treatment
Mammography Ultrasound Optical Imaging MR
CT MR PET/CT Nuclear Medicine
PET/CT Functional Marker
Gene Chips PACS - Electronic Health Record -
Medication Management
F-Angiogenesis PET
PET/CT New Marker
18
Summary

• Need for fundamental change in Healthcare better
  universal patient outcome with cost efficiency
• Personalized healthcare shift from late disease
  to early health
• The convergence of technologies The enabler

19
Imagine

• Your medical data is updated when and where
  needed
• You understand your risks of disease allowing you
  to make better and earlier healthcare choices
• Earlier and more sensitive detection enables
  early treatment and improved quality of life
• Yesterdays biomedical research has enabled
  todays wonder treatments and diagnostics
• You receive right dose of right drug at right
  time
• Follow-on diagnostics quickly confirm treatment
  benefit

20
Preparing for Tomorrow

• "Change is the law of life. And those who look
  only to the past or present are certain to miss
  the future.
• John F Kennedy

21
(No Transcript)
22
(No Transcript)