Title: Chronic Disease Epidemiology
1What is Clinical research And what do we do
it? Ronald E. LaPorte, Ph.D.
2MRC definition of clinical research
The MRC defines clinical research as research based primarily on patients or ex-patients and designed to answer a question about disease (aetiology, concomitants, diagnosis, prevention, outcome or treatment). In addition to direct clinical examination, it includes the study of blood, biopsy material or post-mortem tissue deriving from the individuals concerned and of normal subjects where such study relates to a disease process being investigated. The definition includes clinical trials, and of course much other work on the clinical characterisation of disease or ill health.
3Broadly defined, clinical research involves the
participation of human subjects in various
aspects of research. It is the linchpin of the
Nation's biomedical research enterprise. Clinical
research ultimately establishes the safety,
effectiveness and availability of new diagnostic,
preventive and therapeutic approaches.
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6Why do you want to
be a Scientist?
- Long Hours
- Low pay
- Competition Elite of the Elite
- Nomadic Existence
7Why do you want to be a scientist?
- Passion and Excitement-- the buzz
- Those of us in epidemiology believe that it is
important, exciting, and it is FUN.
Kuller, 1991
8ScienceThe Ultimate Game
Rules
Tools
9Rules of Tenure
10Rules of the Game of Science
11Ethics
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13Wipe Out
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15Scientific Rights
16Errors
17A scientist can be an alcoholic, a braggart, a
murderer, or even a member of a country club and
will be forgiven. But one instance of
deliberately falsifying data brings about eternal
condemnation by his peers.
18Trust
19PublicationWhy do we publish?
- Communication in Science
- Currency
20Inverse Square Law of Publication
- The Square Root of the Publishing Scientists
publish 50 of the work. - Epidemiologists 1600
- 40 people publish 50 of papers
21Where Can Pakistani Scientists Best Compete?
Basic Research Costly Technology
Clinical Research Populations