Excellence in phenotyping: Assessment of oxidative stress and microinflammation

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Excellence in phenotyping Assessment of
oxidative stress and microinflammation
Jan Menne/Hermann Haller Department of
Nephrology Medical School Hannover
haller.hermann_at_mh-hannover.de
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The problem how translate risk factors into
vascular disase ?
Risk factors
Vascular damage subclinical
Clinical disease
glucoselipidssmokinghypertension
years and decades
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The problem how to recognize these patients ?
Risk factors
Vascular damage subclinical
Clinical disease
glucoselipidssmokinghypertension
years and decades
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phenotyping - what are we looking for ?
hypertension
Oxidativestress
Micro-inflammation
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EM Gefäß
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Healthy endothelium
Non-adhesive
NO NOS NO
Permeability
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Hypertension Glucose Cholesterol
risk factors
Healthy endothelium
Non-adhesive
Chemokines
NO NOS NO
Permeability
Permeability
NOS inhibitors
Oxidases
ROS
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Hypertension Glucose Cholesterol
risk factors
Healthy endothelium
Non-adhesive
Chemokines
NO NOS NO
Permeability
Permeability
Oxidases
NOS inhibitors
ROS
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EM Leukozytenadhäsion
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Hypertension Glucose Cholesterol
risk factors
Healthy endothelium
Chemokines MCP-1, CCR-7 etc
Non-adhesive
NO NOS NO
Permeability
Permeability
selectins
Oxidases
NOS inhibitors
ROS