UKs Center for Clinical

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UKs Center for Clinical Translational
Science The Outreach Component October 24,
2006Emery A. WilsonOffice of Health Research
and Development
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Agenda

• Brief Background What is the CTSA?
• Components of the CTSA
• Impact of the CTSA on UK
• RFA Specifics
• UKs Response to the RFA Center for Clinical and
  Translational Science CCTS
• The Outreach Component

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Brief Background What is the NIHs Clinical and
Translational Science Award (CTSA)?
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In the Old Days, NIH Funded

• General Clinical Research Center (CGRC)
• Clinical Research Organization (CRO)
• Training programs (T32, K30, etc.)
• Clinical Research Curriculum Awards
• Program projects
• Individual grants

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NIH Roadmap Initiative the CTSA

• NIH no more business as usual
• NIHs Roadmap Initiatives Clinical
  Translational Science Award, a.k.a. CTSA
• CTSA formal institutional infrastructure for the
  conduct of and training in all aspects of
  clinical translational research
• Goals of the CTSA accelerate the application of
  basic science discoveries to clinical practice,
  and
• Facilitate the communication of observation from
  the
• bedside . bench

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Components of CTSA

• Transformation consolidation of existing
  research and research training services
  programs into an integrated center for clinical
  translational research
• NIH General Clinical Research Center (GCRC)
• Clinical Research Organization (CRO)
• NIH Multidisciplinary Clinical Research Career
  Development Program (Roadmap K12)
• NIH Pre-doctoral Clinical Research Training
  Program (Roadmap T32)
• NIH Clinical Research Curriculum Award (K30)
• Advanced degree programs in clinical/translational
  research

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Components of CTSA

• Transformation consolidation of existing
  research and research training services
  programs into an integrated center for clinical
  translational research
• Institutional Review Board (IRB)
• Office of Sponsored Programs Administration
  (OSPA)
• Institutional Core facilities services
• Co-localization of
• Basic Scientists
• Clinical Scientists
• Translational Researchers
• Community clinicians, practices, networks
• Professional organizations and societies

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Impact on UK

• Will require closer collaboration between basic,
  translational, clinical scientists community
  practitioners
• Lack of an institutional CTSA will impact future
  applications to NIH
• Funding for GCRCs will be phased out over next
  3-5 years
• Roadmap K12 T32 awards will not be renewed
• No home No award

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RFA Specifics

• CTSA Application for full program
• Due date January 17th, 2007
• 38 million for FY07
• Up to 6 million/CTSA direct costs over 5 years
• 8 CTSA awards for FY07
• 60 CTSA awards by 2012

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UKs Response to the RFA

• Center for Clinical and Translational Science
• (CCTS)

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Institutional Restructuring Introduction of the
12 Key Functions 7 Core Units

• 12 Key Functions
• Novel Translational Methodologies
• Pilot Studies
• Bioinformatics
• Design, Biostatistics, Bioethics
• Regulatory Knowledge
• Participant Clinical Interaction Resources
• Community Engagement
• Translational Technology
• Education/Training/Career Development
• Interprofessional Engagement
• Evaluation Assessment
• Access Administration

• 7 Core Structures
• Research Subject Investigational Unit
• Data Management, Methodology, and Biomedical
  Informatics
• Community and Professional Research Engagement
• Training, Education, and Mentoring
• Office of Research Leadership Development
• Administrative
• Bioethics

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Structure/Function Relationship of CCTS Key
Functions and Core Units
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UKs Outreach Component

• Multidisciplinary - Health Sciences, Agriculture,
  Others
• Clinical Enterprise
• Centers for Rural Health
• Hazard, Morehead, Madisonville, Murray
• Statewide network with regional emphasis
• Provide technical assistance
• Partners with other agencies
• Promotes continuity of health professions
  education
• Facilitates development of health workforce
  database
• Facilitates recruitment/retention of health
  professionals
• Provides regional base of Kentucky Homeplace and
  State Office
• Supports collaborative, rural-based research
  (CTSA)

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Closing Remarks

• Visit the CCTS website at www.ctsc.uky.edu

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Thanks to Dr. Balke and Dr. Umberger for some of
the materials for this presentation.
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CCTS Organizational Chart