Cores

1
Cores

• In vivo imaging dosimetry
• Molecular pathology, bioinformatics statistics
• Administrative data sharing
• Need to outline capabilities of each institution
  and also the specific functions of each core.

2
In vivo imaging and dosimetry (Director BRIAN
POGUE, Associate SUNG CHANG)

• ? London core staff
• Distribute basic dosimetry instruments (lasers,
  powermeters, fibers, PDT PS dosimeter) to all
  institutions.
• Develop advanced dosimetry instrumentation
  Open-access Dosimeter Resource (OADR),
  depth-sensitive fiber, singlet oxygen monitor,
  OCT-guided dosimetry for skin (OCT for
  delineating different layers along depth)
• Imaging instrumentation
• Ultrasound
• Commercial fluorescence tomography system
  (Weissleder group)
• MR-guided fluorescence tomography (Brian Pogue)
• Molecular imaging
• Endoscopic intravital microscopy (preliminary
  results)

3
Molecular pathology, bioinformatics
statistics(Director TH, Associate
Imran/Zhiming (?))

• Potential core investigator/core staff
• Jack Hoopes for pathology.
• Yuchiao for statistics.
• Judy Drazba (Cleveland) for LCM.
• ? Potential core investigator/core staff in
  London (?tissue bank manager).
• Marker identification (tools) IHC, PCR, qrtPCR,
  Western, ELISA, immunoblots
• Reporters of molecular response (techniques)
• Bioinformatics connect with Broad Institute and
  look at high throughput assays (identify
  molecules enhance PS production skin and
  cellular molecules that inhibit signaling for
  combination with PDT pancreas)
• Ex vivo samples.
• Cell transfection
• PRELIM DATA
• Contact Broad Institute and establish a
  preliminary screen
• Do IHC on important molecular markers (ie. EGFR)

4
Common major equipment/facility

• 3 comprehensive cancer centers
• Harvard CC
• Cleveland Clinic
• Dartmouth-Hitchcock
• Imaging
• PET (MGH, DH)
• Confocal microscope (MGH, DH, CCF)
• MRI (DH)
• OCT (MGH)
• Maestro (MGH)
• Bioluminescence (MGH, CCF)
• LCM
• Flow cytometry

5
Administrative data sharing(Director TH,
Associate Brian Pogue)

• Organize meetings, reports.
• Open dosimetry resource
• Data sharing
• Website management
• PPG-focused symposia in one of major conferences
• Career advancement
• Official policy on patenting and IP
• Commercialization plans/interaction with industry
• ???? MORE CREATIVE

6
Advisory board members

• Scientific advisory board
• Brian Wilson
• Metastasis person (Ann Chamber?)
• Barbara Henderson, (conflict with Alan Osaroff)
  (?)
• Paul Macdonald (VitD expert at CWRU)
• Elizabeth Jaffee (?,for pancreatic,immunotherapy,J
  ohns Hopkins)
• Clinical advisory board
• Steve Bown
• Ralph Hruban (Johns Hopkins)
• Rox Anderson
• Norm Nishioka/Bill Brugge (?)
• Ask Steve about potential clinical members
• Need an advisory member in the field of molecular
  markers

7
Timelines

• May 22 (Mon)
• aims and hypothesis
• general outline of methods and endpoints
• list of publications
• June 15
• Budgets
• End of July
• Regroup
• Evaluate preliminary data
• More polished version of proposal
• End of August/Beginning of September
• Collect whole draft
• October 1
• Submission