MOLECULAR EVOLUTION MB437 and ADVANCES IN MOLECULAR EVOLUTION MB537

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MOLECULAR EVOLUTION MB437 and ADVANCES IN
MOLECULAR EVOLUTION MB537 Marcie McClure, Ph.D.
,mars_at_parvati.msu.montana.edu, 994-7370 Fall,
2006, Tu/Th 1100-1215 Cooley-B2 Lecture 1
8/29/06 Organization Introduction What is
molecular evolution? Lecture 2 8/31/06
The BIG BANG and formation of the elements
necessary for life. Lecture 3 9/5/06
Biogenesis I The primitive earth and the
prebiotic soup. Lecture 4 9/7/06
Biogenesis II Self-assembly, Energetics
and Bioinformational Molecules. Lecture 5
9/12/06 Biogenesis III Protein
or Nucleic Acids first? RNA or DNA? Lecture 6
9/14/06 The RNA world the
three Domains of life and LUCA. Lecture 7
9/19/06 Origin of the Genetic Code and more
on LUCA Lecture 8 9/21/06
Genomes Content and Architecture. Lecture 9
9/26/06 Mutation nucleotide
substitutions and amino acid replacements. Lecture
10 9/28/06 Methods Analyzing sequences
rates/patterns. Lecture 11 10/3/06
open discussion Lecture 12 10/5/06
Molecular Phylogeny I History, terms,
definitions, and limits. Lecture 13 10/10/06.
Molecular Phylogeny II How to determine a
phylogenetic tree. Lecture 14 10/12/06
Molecular Phylogeny III Improvements and
Extensions to Genome Trees. Lecture 15 10/17/06
NEW? Bayesian and HMM Approaches to
plylogenetic reconstruction Lecture 16 10/19/06
Deviation from Tree-like behavior
horizontal transmission of information Lecture 17
10/24/06 open discussion Lecture 18
10/26/06 Convergent Evolution the
antifreeze story. Lecture 19 10/31/06
Evolution of Viruses Lecture 20 11/2/06
Retroid Agents eukaryotic hosts and disease
states. Lecture 21 11/7/06 UNIVERSITY HOLIDAY
Lecture 22 11/9/06 Bioethics of the
Human Genome Project/ Introduction to
Bioinformatics. Lecture 23 11/14/06
Examples of in silico research I the RNA
polymerase story. Lecture 24 11/16/06
Examples of in silico research II the Genome
Parsing Suite finds Retroid Agents. Lecture 25
11/21/06 Protein Disorder predictions
Measles the elegance of in silico and wet
experiments 11/22-24/06 THANKSGIVING
HOLIDAY Lecture 26 11/28/06 Lecture 27
12/30/06 Lecture 28 12/5/06 Lecture 29
12/7/06
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BASIC OUTLINE OF CLASS

• 1) Speculation and research on the origin of
  life.
• Structure of the arguments
• There are two approaches to the study of the
  origin of life
• From small to large
• From complex to simple
• We will cover six stages
• The Big Bang and formation of the elements
• The early earth environment
• Prebiotic chemistry
• Self-assembly processes
• Energetics
• Bioinformational molecules
• 2) The RNA world as an intermediary to the DNA
  world.
• 3) Genome organization
• 4) Mutation and Phylogenetic Reconstruction
• A) The systematists who study DNA sequence
  relationships with lt20 change.
• B) Molecular pattern recognitionists who
  study protein relationships with lt25
  conservation.
• 5) What are the mechanisms of molecular
  evolution? Special Topics
• 6) Bioethics and Intro to Bioinformatics

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• Where did
• the elements come from?

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The Big Bang Singularity
Hubble
Hawkings
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From big bang singularity to the stars, planet
earth and all life. Without the death
of stars there would be no life.
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This is the first direct image of a star other
than the Sun. Called Alpha Orionis, or
Betelgeuse, the star is a red super giant, a
Sun-like star nearing the end of its life.The
Hubble picture reveals a huge ultraviolet
atmosphere with a mysterious hot spot on the
stellar behemoth's surface. The enormous bright
spot, more than 10 times the diameter of Earth,
is at least 2,000 degrees Kelvin hotter than the
star's surface.
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This is the first direct image of a star other
than the Sun. Called Alpha Orionis, or
Betelgeuse, the star is a red super giant, a
Sun-like star nearing the end of its life.The
Hubble picture reveals a huge ultraviolet
atmosphere with a mysterious hot spot on the
stellar behemoth's surface. The enormous bright
spot, more than 10 times the diameter of Earth,
is at least 2,000 degrees Kelvin hotter than the
star's surface.
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Nuclear fusion LIFE Without fusion we would
not exist.
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May 13, 2004, European astronomers have found a
large disc of dust and gas in nebula M 17, which
seems to be forming a huge star, 30-40 times
larger than our Sun. Astronomers have long known
that low mass stars (like our own Sun) form from
discs, but it wasn't clear if huge stars do this
too. The disc has 110 times the mass of our Sun,
and was seen as a dark silhouette against a hot
region of the nebula. The disc has a diameter of
0.31 light-years, which is 500 times larger than
the orbit of Pluto.
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Nuclear fusion life, without fusion we would
not exist.
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Remnant of the supernova of a high mass star.
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we are stardust, we are golden and weve got to
get ourselves back to the garden. Joni
Mitchell
I am made of stardust and the ocean flow in my
veins Rush