Dr' Sc', Ph'D', Senior specialist

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Dr. Sc., Ph.D., Senior specialist
Photonics
Moscow Regional Research and Clinical Institute
MONIKI named after M.F.Vladimirsky
Speaker Dmitrii Rogatkin
Moscow, RF
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Agenda / content

• Description of the Institute
• Description of the research activities and used
  photonic technique
• General medical problem taken into consideration
  where co-operation is sought
• Project ideas, our experience and background
• Summary

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1. Description of the Institute
Moscow Regional Research and Clinical Institute
MONIKI named after M.F.Vladimirskiy

• One of the oldest State medical institute in
  Russia
• Was founded in 1773
• Multidisciplinary institute
• Around 2000 employees
• Around 300 researchers
• Around 100 Ph.D. and Dr. Sc.
• 3 Members of Russian Academy of Science
• Budget per year is around 150 million USD.

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2. Research activities and used photonic technique
General

• Fundamental and applied research in most main
  areas of medicine
• Oncology, Gastroenterology, Radiology, Surgery,
  Therapy, etc.
• - More than 50 scientific projects, programs and
  contracts per year
• - More than 1000 publications per year.

Photonics
Laser Doppler Flowmetry (LDF)
Laser Noninvasive Medical Spectrophotometry
Laser Fluorescent Diagnostics (LFD)
Tissue Reflectance Oximetry (TRO)
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Laser Doppler Flowmetry (LDF) Technique
Perfusion (pf. un.) Im Ner ? V
?ctive and passive regulation processes
(frequency rhythms) in a microcirculation system
arterioles 23 mm/s
Velocity, V
venules 2,5 mm/s
capillaries 0,3 mm/s
Average magnitude Im
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Tissue Reflectance Oximetry (TRO) technique
?a, mm-1
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Melanin
1
Hb
10-1
Other
HbO2
10-2
capillaries
arterioles
venules
10-3
H2O
10-4
Arterio-venules anastomosis
400 550
700 850
?, nm
Wavelength, nm
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Evaluation of tissues SO2 in TRO
Optical probe
SO2
Sampling volume
SO2a
tissues SO2
2-3 mm
SO2v
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Laser fluorescent diagnostics (LFD)
laser
Backscattering and fluorescent spectra
Content in tissue

• - NADH
• - FP
• - Lipopigments
• - Porphyrin
• - others

tissue
Accumulation of porphyrins
Center of tumor
Intact tissue
Standard scatter
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4. General medical problem which is taken into
consideration and where co-operation is sought
Biophotonics noninvasive laser diagnostics in
radiology
We are looking for the European partner(s) to
study the efficiency of the complex laser
noninvasive diagnostic technique in radiology and
oncology. Medical specialists and research teams
are preferable.
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Radiotherapy of tumors and prognosis of efficacy
Without nearest positive visible results
Others

28,3



75
Head and neck cancer
Direct nearest positive result
Schedule of Dynamic Multifractioning of
Irradiation Doze
Pause 14 days
?
Result
Continue ? Surgery intervention ?
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5. Project ideas, our experience and background
Photonics equipment
Multifunctional laser noninvasive diagnostic
system (MLNDS)
Skin cancers
Pilot model of MLNDS
Oral cavity cancers
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Preliminary results by LFD
Efficacy of radiotherapy of oral cavity cancers
in depend on initial fluorescence of porphyrins
and flavins in the tumor
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Preliminary results by TRO
Evaluation of oxygen status of a tumor (oxygen
uptake in tumor)
SO2sp(100-SO2)/Vb
SO2mSO2/Im
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Tumor perfusion before and after ionizing
irradiation procedure (distant photon therapy
(DPT))
Preliminary results by LDF

• Before irradiation

• 30 min after irradiation

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6. Summary
Biophotonics medical Project

• Title of the Project Complex noninvasive laser
  medical diagnostics in the modern radiology.
• Main idea of the Project clinical research in
  a field of radiology and oncology to study an
  efficacy of laser noninvasive spectrophotometry
  to predict a positive radiotreatment outcome.
• Duration time of the Project 2-3 years.
• It is necessary for the Project to have several
  clinic international platforms for independent
  double (triple) reliable study.

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Thank you !
Contact details
Dr. Dmitrii Rogatkin MONIKI, Shepkina str.
61/2, Moscow, RF rogatkin_at_monikiweb.ru www.monikiw
eb.ru Tel. [phone] Tel. [phone]