Opiates

1
Opiates

• Pain
• Reinforcement, Tolerance, Dependence
• Treatment

2
Pain

• Causes
• Quality
• Emotion
• Quantification

3
Pain

• Early Pain
• Purpose
• Fibers
• Late Pain
• Emotion
• Fibers

4
Opioids and Pain Modulation

• Spinal interneurons
• Descending pathways
• Supraspinal mechanisms

5
Opiate Reinforcement

• Animal studies
• Dopamine
• Others?

6
Opiate Tolerance/Sensitization

• Tolerance
• Cross-tolerance
• Includes endogenous opioids
• Sensitization
• Craving

7
Opiate Dependence

• Withdrawal
• Rebound/Hyperexcitability
• Antagonists
• Symptoms
• Factors

8
Opiate Treatment

• Detox
• Pharmacological support
• Methadone
• LAAM
• Buprenorphine
• Counseling