Optical Biopsy System for Photo-diagnosis of Cancer

1
Optical Biopsy System for Photo-diagnosis of
Cancer

• Martin ODwyer
• With
• Prof. Miles Padgett, Department of Physics and
  Astronomy, University of Glasgow
• and
• Prof. James Ferguson, the Department of
  Photobiology, Ninewells Hospital, Dundee.

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This talk

• The Idea
• The device
• Some work weve done with it (very quickly)
• Risks/Opportunities
• The present plan
• Projections
• Conclusions

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Making cancers fluorescent

• Apply ALA (somehow!)
• Wait 4 hours
• Autofluorescence reduced in Cancers
• Cancers accumulate excess PpIX
• Excitation _at_ 405nm
• Emission _at_ 635nm

405nm
635nm
The PpIX absorption and emission bands
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The Fluorescence Excitation and Measurement System
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Finished System

• Distinguishes between normal and cancerous
  fluorescence.
• Compact, portable, robust and user-friendly
  system.
• Fibre-coupled for endoscopic use.
• Runs off mains supply
• Comparatively cheap
• (sell 8k, cost 4K)

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Endoscopic detection of gastrointestinal (GI)
cancersResults

• Ratio of autofluorescence and PpIX fluorescence
  peaks allows normal and pre-cancerous tissue to
  be clearly distinguished.
• Potential for use in early detection of GI
  cancers.

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Monitoring PDT of anal intraepithelial neoplasia
(AIN) Results

• Clear decrease in PpIX fluorescence during
  treatment due to photobleaching.
• Potential for determining appropriate length of
  treatment.

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Other Current Applications

• Source comparisons
• Characterisation of new formulations in-vivo
• In-vitro study of new drug combinations
• Dermatology Photo-Diagnosis

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Market (in US)

• PDT systems 2500 per annum
• Barrret screening 4.2 million per annum
• Colorectal cancer screening 4 million per annum
• However, Research market easier
• Have sold devices already
• Building up more contacts
• Further interest has been shown
• Proliferation of new applications

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Goals

• Immediate Goals
• Develop business/marketing skills
• Set up a company
• Sell systems soon (Build up some working Capital)
• Medium Goals
• Viable business
• Expand applications/market for current product
• R/D new products (some ideas already)
• Consumables
• Long term Goal
• Establish recognisable business with branded
  range of products/services
• Make Profit

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Risks/Advantages

• Liability/IP litigation/Non-acceptance/no new
  products
• (competitor too)
• Lack of skill/Lack of manufacturing ability
• (competitor advantages)
• Photonics use increasing/Market growing
• (competitors too)
• Lower cost base/cheaper portable product
• (competitor disadvantage)

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SWOT

• Strengths
• Less prone to economic cycle
• Increasing spending, Bio-Photonics growing
• Weaknesses
• Highly regulated
• Highly competitive
• Opportunities
• Improving technology
• Increased demand
• Threats
• Inefficiency in system
• Better alternatives

13
Sales
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Gross Profit Projections
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Conclusion

• Have a product (commercially viable ?)
• Have a strategy to develop market
• Developing business skills to achieve strategic
  goals
• Funding allows time dedicated to developing
  business and promoting product