Embriologi Alat Kelamin Deferensiasi Sex

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Embriologi Alat Kelamin(Deferensiasi Sex)
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• Embriologi Alat Kelamin
• (Deferensiasi Sex)
• 1. Teori hormon ? Free Martin
• 2. Teori kimerisme ? XX XY
• 3. Teori induktor kortiko medula ?
• Medullary versus Kortisin

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• Primordial germ cell Primordial germ
  cell
• Spermatozoa Ovum
• Sigot
• Embrio
• primordial germ cell
• Spermatozoa Ovum

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• Stadium Indiferen
• 
  Endoderm
• Fertilisasi
• 
  Primordial Germ Cell
• Germinal Ridge Genital Ridge
• (sel-sel mesoderm)
• Ginjal Gonadal Ridge
• Saluran Cortex Medula
• Urogenitalis
• Ovarium Testis

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• Migrasi Germ Cell
• Aktif gerakan amuboid (reptilia, mamalia)
• Pasif aliran darah (burung)
• Faktor-faktor yang mempengaruhi jenis kelamin
• Sex chromosome saat terjadinya fertilisasi ( X
  Y )
• Hormonal ( androgen estradiol )
• Mullerian Inhibition Substances (Fost, 1981)
• (fetal testis)
• regresi saluran Muller H.
  androgen tinggi
• perkembangan saluran kelamin jantan

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• Komponen pembentuk gonad
• Primordial Germ Cell / SGP (ekstra embrionic
  yaitu endoderm yolk sack)
• Coelomic Epithelium
• Sel Mesenchym (dari mesonephric ridge)
• Germ Cell Genital Ridge
• Asal endoderm mesoderm
• Ø sel kecil besar

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• In the female, the mesonephric ducts degenerate,
  while the paramesonephric ducts form the
  fallopian tubes and uterus.

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• The urogenital ridge consists of the mesonephros
  and the gonad.

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• Both the urinary and genital components of the
  urogenital system are derived, to a large extent,
  from the intermediate mesoderm.

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• Descent of the testes carries the cranial end of
  the mesonephric duct caudally.

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• The testes descend into the scrotal swellings,
  following the course of the gubernaculum.

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• In the female, the primitive sex cords (medullary
  cords) degenerate. Subsequently, there is no
  communication between the gonad and the
  mesonephros.

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• In the male the primitive sex cords (see image
  10) form the testis and the rete testis cords.
  The latter communicate with tubules of the
  mesonephric system, thus linking the testis to
  the mesonephric duct. The mesonephric duct
  becomes the ductus deferens.

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• In addition to the mesonephric duct, a
  paramesonephric duct forms from the the
  epithelium on the surface of the urogenital
  ridge. In the male, the mesonephric duct is of
  greater significance, whereas in the female, the
  paramesonephric duct is predominant.

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• The primordial germ cells become surrounded by
  cells of the primitive sex cords. At this stage
  the gonad is "indifferent," as one cannot
  morphologically distinguish between the male and
  female.

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• The gonads develop as primordial germ cells that
  form in the wall of the yolk sac close to the
  allantois migrate along the dorsal mesentery of
  the hindgut to invade the genital ridges.

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• The mesonephros consists of excretory tubules
  that contact a blood vessel medially and enter
  the mesonephric (Wolffian) duct laterally. At
  higher magnification

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• DEVELOPMENT HOMOLOGUES OF MALE FEMALE
• Genital System
• Male Indifferent Stage Female
• 1. Testis Gonad Ovary
• 2. Epidydymis duct mesonephric
  duct bladder
• defferent duct (Wolffian duct) epophorus
• 3. Prostaticus paramesonephric duct uterine tube
• (Mullerian duct) uterus
• 4. Glands penis Glans of pallus Glands
• clitoris
• 5. Scrotum genital swelling labia majora
• 6. Urethra penil urethral fold labia minor