NIH Support for Engineering Research

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NIH Support for Engineering Research

• Donna J. Dean, Ph.D.
• ASEE ERC Forum and Workshop
• Arlington, VA
• February 25, 2003

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Mastery of the life sciences is the most complex
scientific challenge ever faced by humankind.It
will define this century.- Elias Zerhouni,
M.D.Director, National Institutes of Health
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Defining a Vision for NIH Research Strategies

• New Pathways to Discovery
• Multidisciplinary Research Teams of the Future
• Re-engineering the Clinical Research Enterprise

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Biomedical Imaging and Bioengineering at NIH

• Where and how NIBIB interacts with NIHs other
  Institutes and Centers
• Key principles and concepts
• Organizational structure that facilitates
  cross-cutting and platform capabilities

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www.nibib.nih.gov
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NIBIB Goals

• Develop fundamental new knowledge
• Foster potent new technologies
• Nurture new generation of researchers
• Facilitate cross-cutting capabilities

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Broad Mission of the NIBIB

• Improve health by supporting and conducting
  focused and multi-disciplinary research and
  research training in biomedical imaging and
  bioengineering.
• This includes supporting the development and
  translation of emerging technologies that enable
  fundamental discoveries and facilitate disease
  detection, management and prevention.

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Research Training Opportunities

• Bioengineering research partnerships
• Bioengineering research grants
• Career level training
• Pre-doctoral training
• Summer research training

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National Institutes of Health
Office of the Director
National Institute on Alcohol Abuse and Alcoholism
National Institute of Arthritis
and Musculoskeletal and Skin Diseases
National Cancer Institute
National Institute on Aging
National Institute of Child Health and
Human Development
National Institute of Allergy and Infectious
Diseases
National Institute of Diabetes and Digestive
and Kidney Diseases
National Institute of Dental and Craniofacial Rese
arch
National Institute on Drug Abuse
National Institute of Environmental Health
Sciences
National Institute on Deafness and
Other Communication Disorders
National Eye Institute
National Human Genome Research Institute
National Heart, Lung, and Blood Institute
National Institute of Mental Health
National Institute of Neurological Disorders
and Stroke
National Institute of General Medical Sciences
National Institute of Nursing Research
National Library of Medicine
National Center for Complementary and
Alternative Medicine
National Center on Minority Health and Health
Disparities
National Institute of Biomedical Imaging and
Bioengineering
Fogarty International Center
National Center for Research Resources
Center for Information Technology
Center for Scientific Review
Clinical Center
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(No Transcript)
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BECON Symposia

• Bioengineering - 1998
• Biomedical Imaging 1999
• Nanoscience and Nanotechnology 2000
• Reparative Medicine 2001
• Sensors 2002
• Catalyzing Team Science - 2003

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PHS 398 Grant Application

• Specific Aims Section Now States
• List the broad, long-term objectives and what the
  specific research proposed in this application is
  intended to accomplish, e.g., to . . .

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PHS 398 Grant Application

• test a stated hypothesis,
• create a novel design,
• solve a specific problem, or
• develop new technology

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NIBIB Funding History
Dollars in Millions
NIBIB Established
Fiscal Year
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Current NIBIB Portfolio Areas

• Biosensors
• Biomaterials
• Biomechanics
• Bioinformatics
• Computational Biology
• Drug Gene Delivery
• Image Guided Therapies
• Medical Devices/ Implants
• MRI / MRS

• Nanotechnology
• Nuclear Medicine
• Optical Imaging
• Platform Technologies
• Rehabilitation Engineering
• Surgical Techniques Tools
• Tissue Engineering
• Ultrasonics
• X ray, EM, Ion Beam

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RFAs in FY03

• Operation of sensors in vivo
• Improvements in imaging methods and technologies
• Telehealth technologies development
• R D of systems and methods for cellular and
  molecular imaging

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RFAs in FY03

• Small animal imaging systems methods
• Development of advanced biomaterials
• Image-guided interventions
• Tissue engineering

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RFAs in FY03

• Development of novel drug and gene delivery
  systems and devices
• Low cost medical imaging devices
• Global health research initiative (with FIC)
• Noninvasive measurement of iron by MRI (with
  NIDDK)

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Collaborations with Other Agencies

• NIH/NSF Bioengineering Bioinformatics Summer
  Institutes Program (BBSI) 6M for 4 yrs
• Biophotonics Program with NSF - new
• Multi-Agency Tissue Engineering Science (MATES)
  with NSF, NIST, DARPA, DOE etc.
• National Nanotechnology Initiative
• Bioengineering Materials Applications (BEMA)
  Roundtable with NRC/IOM
• Biomedical Information and Science Technology
  Initiative (BISTIC)

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NIBIB Scientific Staff

• Division of Extramural Activities
• Joan Harmon, Ph.D., Director
• Meredith Temple-OConnor, Ph.D.
• David George, Ph.D., Chief, Office of Scientific
  Review
• Scientific Programs
• William Heetderks, Ph.D.., M.D.
• Christine Kelley, Ph.D. Todd Merchak, B.S.
• Grace Peng, Ph.D. Anna Retzke, B.S.
• Peter Moy, Ph.D. Stephen Green, B.S.
• Mary Pastel, Sc.D.
• John Haller, Ph.D.
• Brenda Korte, Ph.D.
• Alan McLaughlin, Ph.D.
• Peter Kirchner, M.D. (on detail from Oak Ridge
  Natl. Lab)
• Richard Swaja, Ph.D. Mollie Sourwine,
  M.S..

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Future Directions

• Bioengineering and biomedical imaging research
  training
• Tissue engineering and regenerative medicine
• Functional cell imaging
• Biomedical optics In vivo monitoring and imaging
  applications

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Bioengineering and biomedical imaging research
training

• Interdisciplinary training at all career levels
  from undergraduate through senior career levels
• Recommendations from Joint NIH/NSF workshop on
  training and NIBIB workshop on training
• Questions/suggestions to Dr. Richard Swaja

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Tissue engineering and regenerative medicine

• Reach a fundamental understanding of structure -
  function relationships in normal and diseased
  tissue and develop substitutes for diseased
  tissue
• Recommendations from BECON conference on
  reparative medicine, multi-agency study on tissue
  engineering science
• Questions/suggestions to Dr. Christine Kelley

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Functional cell imaging

• Observation of processes at the cellular level,
  including gene expression, enzyme activity, and
  metabolism
• Recommendations from BECON symposium Biomedical
  imaging Visualizing the future, and the NIDDK
  conference Imaging the pancreatic beta cell
• Questions/suggestions to Dr. Brenda Korte

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Biomedical optics In vivo monitoring and imaging
applications

• Development of improved optical imaging
  techniques and enabling technologies including
  light sources, detectors, and signal processing
• Recommendations from NIH optical imaging
  workshop, BECON Biomedical imaging workshop,
  NIBIB futures meeting
• Questions/suggestions to Dr. Brenda Korte

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