T cell Activation

1
T cell Activation
Seung-Hyo Lee ??????? (3106?), Phone 4235
E-mail Seung-Hyo.Lee_at_kaist.ac.kr
2
1. CD4 T cell Activation
Overview
2. Activation of CD8 T cells
3. Co-stimulatory Signals
4. Signal Transduction through TcR complex
3
Previous Summary

• CD4 T cell Activation
• Clonal Expansion
• Differentiaion
• Activate Macrophage/B cell
• CD8 T cell Activation
• Clonal Expansion/Differentiation
• Killing Mechanism

4
Function of Co-stimulation
5
Co-stimulatory Molecules
6
Function of CD40
7
Kinetics of Gene Expression
8
T cell Activation Signaling
9
Protein Tyrosine Kinase and Phosphatase
10
Early Event in T cell Activation
11
Immunological Synapse
12
MAP Kinase Pathway
13
PLCg1 Pathway
14
Activation of Tx Factors
15
Mechanisms of CTLA-4 Function
16
Function of Ubiquitin
17
Function of Cbl-b
18
Summary

• Co-Stimulatory Signals
• Activation
• Inhibition
• Signal Transduction
• T cell Activation Signaling
• Activation of Tx Factors
• Termination Signaling