Carl Zeiss MicroImaging AIS

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• Carl Zeiss MicroImaging AIS
• Solutions for Digital
• Pathology
• Andrew Lesniak
• Director, Product Management

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UpdateZeiss, Trestle, Clarient (ACIS)

• The Device technology group was acquired from
  Clarient Inc., by Carl Zeiss in March 2007.
  Combined installation base of 600 Units
  worldwide.
• Full acquisition including both the Trestle and
  the ACIS family of products
• New entity formed under Carl Zeiss Carl Zeiss
  MicroImaging AIS
• Commitment to the technology portfolio,
  including
• Integration into the Carl Zeiss Support structure
  (worldwide).
• Committed RD investments for technology
  enhancement.
• Interoperability with the existing Zeiss product
  portfolio including Image Acquisition, Mirax
  Platforms, and advanced technologies such as the
  PALM MicroBeam platform for Genomic and Phenotype
  applications.

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Leveraging a Leading Product Portfolio for
a Complete Pathology Imaging Solution
Light Microscopy
Advanced Imaging Microscopy
Digital Pathology Solutions
Classical Technologies
Imaging
Laser
Digital Detection
Technology
macro
cellular
molecular

• Applications For Digital Pathology Information
  Management
• Leading Computer Aided Diagnostics and Analysis
• AP Workflow and Educational Data Management

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Scalable Product Constellation
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MIRAX Lab Automation Digital Pathology Solution

• Small footprint
• 20x Plan-Apo objective with 0.8 NA
• Image capture from barcode area w/ barcode
  identification
• Optional 40x Plan-Apo objective with 0.95 NA
• Choice of different camera adaptors (1x or 0.63x)
• Optovar option (1.25x and 1.6x)
• Fluorescence option

Resolution range from 0.11 µm/pixel ... 0.52
µm/pixel
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MIRAX Micro Robotic Digital Pathology Solution

• Zeiss Microscope Platform and Optics
  Configuration
• Full Robotic Telepathology functionality,
  including focal control, condenser settings
• Scalable to Digital Whole Slide Acquisition with
  user selectable Objective (4, 10, 20, 40, 60)
• Multi-focal plane imaging and robust focus
  technology ensures for robust imaging capability.
• Automated Slide Handling of 1, 4, 50 slides
• Fluorescence Multi-Channel Capable

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Unique Scanning Advancements MicroField
Acquisition
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Scanning Advancements Multi-channel Fluorescence
Acquisition
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Digital Pathology Analysis Innovations with
Imaging

• Tissue Scoring and Quantitative Analysis
• Membrane Stains
• Nuclear stains
• Integrated Optical Density
• Rare Event Detection
• Sentinel Lymph nodes
• Bone marrow
• Object Detection and Counting
• Nuclear Cell Counting,
• Micro-Vessel Density, Ploidy
• Tissue Micro Array Scoring

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Digital Pathology Analysis Cellular
Classification in Cytospin
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Digital Pathology Workflow Enabling Scale

• Workflow, Educational and Reference Materials
• Virtual Lab creation- organization of
• Digital Images by context
• Linking a slide to relevant accession,
• histological and pathological context
• information
• Linking areas of interest on a slide
• to relevant teaching or lesion specific
• information
• Preservation of compound related
• effects for future reference

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