Web Site

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Web Site
http//www.ag.uidaho.edu/mmbb/lfort/wwami524/home.
html
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I-II
Gene Silencing
3
II
ICF - IMMUNODEFICIENCY-CENTROMERIC
INSTABILITY-FACIAL ANOMALIES SYNDROME
Mutation in the DNMT3B gene
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DNA methylation is heritable
II
5
Genetic imprinting
III
6
III
Genetic imprints are clustered and encode either
a paternal or maternal methylation
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III
maternal
paternal
The Prader Willi/Angelmans Syndrome Imprinted
Locus
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III
Angelman Syndrome
Prader-Willi Syndrome
Severe mental retardation Seizures Ataxic
gate Jerky movements Lack of speech Microencephaly
Frequent smiling and laughter
Short stature Mental retardation Hypotonia Abnorma
lly small hands and feet Hypogonadism Uncontrolled
appetite leading to extreme obesity
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IV
X-inactivation
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IV
Mechanism of X-inactivation
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Genetic Reprogramming during Embryogenesis
V
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The problems with cloning.
V
13
V
Nuclear cloning
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Topic 6 summary